Literature DB >> 8405398

Vitamin B6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver.

T Oka1, N Komori, M Kuwahata, T Sassa, I Suzuki, M Okada, Y Natori.   

Abstract

The effect of vitamin B6 deficiency on the activity of RNA polymerase and expression of several mRNAs in rat liver was investigated. The activities of RNA polymerase I and II in the liver of vitamin B6-deficient rats were found to be higher than the control rats by 30%. The expression of several mRNAs, including mRNAs for beta-actin and glyceraldehyde-3-phosphate dehydrogenase, and the content of poly(A)+ RNA were also increased in vitamin deficiency. These observations suggest that vitamin B6 influences gene expression in the liver, at least in part, by modulating the activity of RNA polymerase.

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Year:  1993        PMID： 8405398     DOI： 10.1016/0014-5793(93)80318-o

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

1.  Liver-specific increase of UTP and UDP-sugar concentrations in rats induced by dietary vitamin B6-deficiency and its relation to complex N-glycan structures of liver membrane-proteins.

Authors:  Agnes B Renner; Kathrin Rieger; Detlef Grunow; Martin Zimmermann-Kordmann; Martin Gohlke; Werner Reutter
Journal:  Glycoconj J       Date:  2007-06-19       Impact factor: 2.916

2.  Effect of vitamin B6 deficiency on the expression of glycogen phosphorylase mRNA in rat liver and skeletal muscle.

Authors:  T Oka; N Komori; M Kuwahata; I Suzuki; M Okada; Y Natori
Journal:  Experientia       Date:  1994-02-15

3.  Vitamin B6 modulates expression of albumin gene by inactivating tissue-specific DNA-binding protein in rat liver.

Authors:  T Oka; N Komori; M Kuwahata; M Okada; Y Natori
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857
  3 in total

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