Literature DB >> 8405368

An interaction of beta-amyloid with aluminium in vitro.

C Exley1, N C Price, S M Kelly, J D Birchall.   

Abstract

We have used circular dichroism spectroscopy to confirm that, in a membrane-mimicking solvent, A beta P(1-40) adopts a partially helical conformation and we have demonstrated the loss of this structure in the presence of physiologically relevant concentrations of aluminium. This is the first evidence of a direct biochemical interaction between aluminium and beta-amyloid and may have important implications for the pathogenesis of Alzheimer's disease.

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Year:  1993        PMID： 8405368     DOI： 10.1016/0014-5793(93)80137-j

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

1.  Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK.

Authors:  C Exley; M M Esiri
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-04-20       Impact factor: 10.154

2.  Metal cations defibrillize the amyloid beta-protein fibrils.

Authors:  V P Chauhan; I Ray; A Chauhan; J Wegiel; H M Wisniewski
Journal:  Neurochem Res       Date:  1997-07       Impact factor: 3.996

Review 3.  Clinical effects of chemical exposures on mitochondrial function.

Authors:  Zarazuela Zolkipli-Cunningham; Marni J Falk
Journal:  Toxicology       Date:  2017-07-27       Impact factor: 4.221

Review 4.  Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer's Disease.

Authors:  Md Tanvir Kabir; Md Sahab Uddin; Sonia Zaman; Yesmin Begum; Ghulam Md Ashraf; May N Bin-Jumah; Simona G Bungau; Shaker A Mousa; Mohamed M Abdel-Daim
Journal:  Mol Neurobiol       Date:  2020-09-05       Impact factor: 5.590

5.  Interaction of synthetic Alzheimer beta-protein-derived analogs with aqueous aluminum: a low-field 27Al NMR investigation.

Authors:  S B Vyas; L K Duffy
Journal:  J Protein Chem       Date:  1995-11

6.  The conformation of Alzheimer's beta peptide determines the rate of amyloid formation and its resistance to proteolysis.

Authors:  C Soto; E M Castaño
Journal:  Biochem J       Date:  1996-03-01       Impact factor: 3.857

7.  Stable intrachain and interchain complexes of neurofilament peptides: a putative link between Al3+ and Alzheimer disease.

Authors:  M Hollósi; Z M Shen; A Perczel; G D Fasman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

8.  Immuno-detection of aluminium and aluminium induced conformational changes in calmodulin--implications in Alzheimer's disease.

Authors:  R Levi; T Wolf; G Fleminger; B Solomon
Journal:  Mol Cell Biochem       Date:  1998-12       Impact factor: 3.396

9.  Solubilization of beta-amyloid-(1-42)-peptide: reversing the beta-sheet conformation induced by aluminum with silicates.

Authors:  G D Fasman; A Perczel; C D Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1995-01-17       Impact factor: 11.205

Review 10.  Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation.

Authors:  Tee Jong Huat; Judith Camats-Perna; Estella A Newcombe; Nicholas Valmas; Masashi Kitazawa; Rodrigo Medeiros
Journal:  J Mol Biol       Date:  2019-01-18       Impact factor: 5.469
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