| Literature DB >> 8405073 |
G Clementi1, M Amico-Roxas, A Caruso, V M Cutuli, S Maugeri, A Prato.
Abstract
Intravenous administration of calcitonin gene-related peptide (CGRP) prevented in a dose-dependent manner reserpine-induced gastric mucosal damage, but failed to affect the lesions produced by ethanol administration. In pylorus-ligated rats, CGRP significantly reduced gastric volume, total acid and peptic activity output as well as ulcer formation. These protective effects of CGRP were not present when rats were pretreated with cysteamine. Our data suggest that CGRP exerts its antisecretory and antiulcer activity, at least in part, by interfering with somatostatin transmission.Entities:
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Year: 1993 PMID： 8405073 DOI： 10.1016/0014-2999(93)90511-f
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432