OBJECTIVE: To examine the relationship between the prevalence of gallbladder disease and severity of glycemia among diabetic individuals and to provide insight into whether the diabetes-gallstone association is a causal one, because NIDDM patients have an increased prevalence of clinical gallbladder disease. RESEARCH DESIGN AND METHODS: We examined 462 diabetic individuals identified during the San Antonio Heart Study, a population-based survey of diabetes and cardiovascular disease in Mexican Americans and non-Hispanic whites. Diabetes was diagnosed according to National Diabetes Data Group criteria. RESULTS: The prevalence of self-reported gallbladder disease was 34.2% in diabetic women and 7.2% in diabetic men. Although duration of diabetes was positively related to the prevalence of gallbladder disease (P < 0.01), type of therapy was not associated, and fasting glucose concentration was inversely associated with gallbladder disease. CONCLUSIONS: Factors other than hyperglycemia may account for the increased prevalence of gallbladder disease in diabetic subjects.
OBJECTIVE: To examine the relationship between the prevalence of gallbladder disease and severity of glycemia among diabetic individuals and to provide insight into whether the diabetes-gallstone association is a causal one, because NIDDMpatients have an increased prevalence of clinical gallbladder disease. RESEARCH DESIGN AND METHODS: We examined 462 diabetic individuals identified during the San Antonio Heart Study, a population-based survey of diabetes and cardiovascular disease in Mexican Americans and non-Hispanic whites. Diabetes was diagnosed according to National Diabetes Data Group criteria. RESULTS: The prevalence of self-reported gallbladder disease was 34.2% in diabeticwomen and 7.2% in diabeticmen. Although duration of diabetes was positively related to the prevalence of gallbladder disease (P < 0.01), type of therapy was not associated, and fasting glucose concentration was inversely associated with gallbladder disease. CONCLUSIONS: Factors other than hyperglycemia may account for the increased prevalence of gallbladder disease in diabetic subjects.
Authors: Sobha Puppala; Gerald D Dodd; Sharon Fowler; Rector Arya; Jennifer Schneider; Vidya S Farook; Richard Granato; Thomas D Dyer; Laura Almasy; Christopher P Jenkinson; Andrew K Diehl; Michael P Stern; John Blangero; Ravindranath Duggirala Journal: Am J Hum Genet Date: 2006-01-06 Impact factor: 11.025
Authors: Veronica Escobar; S Liliana Oakes; Robert Wood; Johanna Becho; Kyriakos Markides; David V Espino Journal: Aging Clin Exp Res Date: 2009-02 Impact factor: 3.636