Literature DB >> 8403192

Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA.

A R Collins1, S J Duthie, V L Dobson.   

Abstract

The endogenous production of oxidative damage in DNA by free radicals released as a by-product of respiration is a likely cause of mutations which, if they occur in appropriate genes, may lead to cancer. Using an endonuclease specific for oxidized pyrimidines, in conjunction with the highly sensitive method of single cell gel electrophoresis, we have detected significant oxidative damage in untreated, freshly isolated lymphocytes from normal, healthy individuals.

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Year:  1993        PMID： 8403192     DOI： 10.1093/carcin/14.9.1733

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  88 in total

1.  Oxidative damage to DNA and single strand break repair capacity: relationship to other measures of oxidative stress in a population cohort.

Authors:  Andrzej R Trzeciak; Joy G Mohanty; Kimberly D Jacob; Janice Barnes; Ngozi Ejiogu; Althaf Lohani; Alan B Zonderman; Joseph M Rifkind; Michele K Evans
Journal:  Mutat Res       Date:  2012-01-18       Impact factor: 2.433

Review 2.  New applications of the Comet assay: Comet-FISH and transcription-coupled DNA repair.

Authors:  Graciela Spivak; Rachel A Cox; Philip C Hanawalt
Journal:  Mutat Res       Date:  2008-01-17       Impact factor: 2.433

3.  Micronuclei and chromosome aberrations in subjects occupationally exposed to antineoplastic drugs: a multicentric approach.

Authors:  Massimo Moretti; Maria Giuseppa Grollino; Sofia Pavanello; Roberta Bonfiglioli; Milena Villarini; Massimo Appolloni; Mariella Carrieri; Laura Sabatini; Luca Dominici; Laura Stronati; Giuseppe Mastrangelo; Anna Barbieri; Cristina Fatigoni; Giovanni Battista Bartolucci; Elisabetta Ceretti; Francesca Mussi; Silvano Monarca
Journal:  Int Arch Occup Environ Health       Date:  2014-11-02       Impact factor: 3.015

4.  Genotoxicity of the herbicide imazethapyr in mammalian cells by oxidative DNA damage evaluation using the Endo III and FPG alkaline comet assays.

Authors:  Sonia Soloneski; Celeste Ruiz de Arcaute; Noelia Nikoloff; Marcelo L Larramendy
Journal:  Environ Sci Pollut Res Int       Date:  2017-03-07       Impact factor: 4.223

Review 5.  Formation and repair of oxidatively generated damage in cellular DNA.

Authors:  Jean Cadet; Kelvin J A Davies; Marisa Hg Medeiros; Paolo Di Mascio; J Richard Wagner
Journal:  Free Radic Biol Med       Date:  2017-01-02       Impact factor: 7.376

Review 6.  Markers of oxidant stress that are clinically relevant in aging and age-related disease.

Authors:  Kimberly D Jacob; Nicole Noren Hooten; Andrzej R Trzeciak; Michele K Evans
Journal:  Mech Ageing Dev       Date:  2013-02-18       Impact factor: 5.432

7.  Assessment of individual susceptibility to baseline DNA and cytogenetic damage in a healthy Turkish population: evaluation with lifestyle factors.

Authors:  Ela Kadioglu; Neslihan Aygun Kocabas; Gonca Cakmak Demircigil; Erdem Coskun; Eren Ozcagli; Emre Durmaz; Bensu Karahalil; Sema Burgaz; Semra Sardas
Journal:  Genet Test Mol Biomarkers       Date:  2012-08-20

8.  In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay.

Authors:  V Sipinen; J Laubenthal; A Baumgartner; E Cemeli; J O Linschooten; R W L Godschalk; F J Van Schooten; D Anderson; G Brunborg
Journal:  Mutagenesis       Date:  2010-05-20       Impact factor: 3.000

9.  Fluorescence in situ hybridization in combination with the comet assay and micronucleus test in genetic toxicology.

Authors:  Galina G Hovhannisyan
Journal:  Mol Cytogenet       Date:  2010-09-15       Impact factor: 2.009

10.  DNA damage/repair and polymorphism of the hOGG1 gene in lymphocytes of AMD patients.

Authors:  Katarzyna Wozniak; Jacek P Szaflik; Malgorzata Zaras; Anna Sklodowska; Katarzyna Janik-Papis; Tomasz R Poplawski; Janusz Blasiak; Jerzy Szaflik
Journal:  J Biomed Biotechnol       Date:  2009-10-26
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