Literature DB >> 8402951

Anesthesia inhibits interferon-induced natural killer cell cytotoxicity via induction of CD8+ suppressor cells.

S N Markovic1, D M Murasko.   

Abstract

Anesthesia (Avertin, halothane, isoflurane, ether, or ketamine/xylazan) of mice inhibits subsequent stimulation of splenic natural killer cell (NK) cytotoxicity by interferon (IFN) treatment either in vitro and in vivo. The current data demonstrate (a) in vitro depletion of CD8+ cells from mononuclear splenocytes of anesthetized mice restored the ability of NK cells to respond in vitro to IFN stimulation and (b) coincubation of CD8+ splenocytes from anesthetized mice with CD8- splenocytes of naive mice resulted in a significant reduction of the IFN-induced stimulation of NK activity in the coculture. These results suggest that anesthesia induces CD8+ cells that suppress stimulation of NK cytotoxicity by IFN.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8402951     DOI： 10.1006/cimm.1993.1256

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  15 in total

Review 1.  Anesthetics, immune cells, and immune responses.

Authors:  Shin Kurosawa; Masato Kato
Journal:  J Anesth       Date:  2008-08-07       Impact factor: 2.078

Review 2.  Relationship between Volatile Anesthetics and Tumor Progression: Unveiling the Mystery.

Authors:  Bo Jiao; Chun Yang; Nian-Nian Huang; Ning Yang; Jia Wei; Hui Xu
Journal:  Curr Med Sci       Date:  2018-12-07

3.  An Inhibitor of the Mitochondrial Permeability Transition Pore Lacks Therapeutic Efficacy Following Neonatal Hypoxia Ischemia in Mice.

Authors:  Jing Fang; Raul Chavez-Valdez; Debbie L Flock; Oliver Avaritt; Manda Saraswati; Courtney Robertson; Lee J Martin; Frances J Northington
Journal:  Neuroscience       Date:  2019-03-05       Impact factor: 3.590

4.  Accumulation of PSA-NCAM marks nascent neurodegeneration in the dorsal hippocampus after neonatal hypoxic-ischemic brain injury in mice.

Authors:  Raul Chavez-Valdez; Charles Lechner; Paul Emerson; Frances J Northington; Lee J Martin
Journal:  J Cereb Blood Flow Metab       Date:  2020-07-23       Impact factor: 6.200

5.  Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model.

Authors:  Raul Chavez-Valdez; Paul Emerson; Janasha Goffigan-Holmes; Alfredo Kirkwood; Lee J Martin; Frances J Northington
Journal:  Hippocampus       Date:  2018-08       Impact factor: 3.899

6.  Calbindin-1 Expression in the Hippocampus following Neonatal Hypoxia-Ischemia and Therapeutic Hypothermia and Deficits in Spatial Memory.

Authors:  Janasha Goffigan-Holmes; Dafne Sanabria; Johana Diaz; Debra Flock; Raul Chavez-Valdez
Journal:  Dev Neurosci       Date:  2019-03-12       Impact factor: 2.984

7.  Sexual dimorphism in BDNF signaling after neonatal hypoxia-ischemia and treatment with necrostatin-1.

Authors:  R Chavez-Valdez; L J Martin; S Razdan; E B Gauda; F J Northington
Journal:  Neuroscience       Date:  2013-12-17       Impact factor: 3.590

8.  Endoplasmic reticulum pathology and stress response in neurons precede programmed necrosis after neonatal hypoxia-ischemia.

Authors:  Raul Chavez-Valdez; Debbie L Flock; Lee J Martin; Frances J Northington
Journal:  Int J Dev Neurosci       Date:  2015-11-28       Impact factor: 2.457

9.  Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia.

Authors:  R Chavez-Valdez; L J Martin; D L Flock; F J Northington
Journal:  Neuroscience       Date:  2012-05-11       Impact factor: 3.590

10.  Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses.

Authors:  Daisuke Hayasaka; Francis A Ennis; Masanori Terajima
Journal:  Virol J       Date:  2007-02-27       Impact factor: 4.099
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.