Literature DB >> 8402657

Prevention of carcinogenicity of anticancer drugs by metallothionein induction.

M Satoh1, Y Kondo, M Mita, I Nakagawa, A Naganuma, N Imura.   

Abstract

We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8402657

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  8 in total

1.  Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy.

Authors:  Stephen D Dertinger; Svetlana L Avlasevich; Dorothea K Torous; Jeffrey C Bemis; Souk Phonethepswath; Carson Labash; Kristine Carlson; Jared Mereness; John Cottom; James Palis; James T MacGregor
Journal:  Toxicol Sci       Date:  2014-05-05       Impact factor: 4.849

2.  Potential effect on cellular response to cadmium of a single-nucleotide A --> G polymorphism in the promoter of the human gene for metallothionein IIA.

Authors:  Kayoko Kita; Nobuhiko Miura; Minoru Yoshida; Kentaro Yamazaki; Takayoshi Ohkubo; Yutaka Imai; Akira Naganuma
Journal:  Hum Genet       Date:  2006-08-23       Impact factor: 4.132

3.  Bismuth adjuvant ameliorates adverse effects of high-dose chemotherapy in patients with multiple myeloma and malignant lymphoma undergoing autologous stem cell transplantation: a randomised, double-blind, prospective pilot study.

Authors:  Per Boye Hansen; Milena Penkowa
Journal:  Support Care Cancer       Date:  2016-12-13       Impact factor: 3.603

4.  Zinc mediated normalization of histoarchitecture and antioxidant status offers protection against initiation of experimental carcinogenesis.

Authors:  Vijayta Dani Chadha; K Vaiphei; D K Dhawan
Journal:  Mol Cell Biochem       Date:  2007-05-26       Impact factor: 3.396

Review 5.  Zinc: a promising agent in dietary chemoprevention of cancer.

Authors:  D K Dhawan; Vijayta D Chadha
Journal:  Indian J Med Res       Date:  2010-12       Impact factor: 2.375

6.  ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype.

Authors:  Monserrat Olea-Flores; Julia Kan; Alyssa Carlson; Sabriya A Syed; Cat McCann; Varsha Mondal; Cecily Szady; Heather M Ricker; Amy McQueen; Juan G Navea; Leslie A Caromile; Teresita Padilla-Benavides
Journal:  Front Cell Dev Biol       Date:  2022-07-11

7.  Metallothionein induction reduces caspase-3 activity and TNFalpha levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats.

Authors:  Gouda K Helal; Abdulaziz M Aleisa; Omayma K Helal; Salim S Al-Rejaie; Abdulaziz A Al-Yahya; Abdulhakeem A Al-Majed; Othman A Al-Shabanah
Journal:  Oxid Med Cell Longev       Date:  2009 Jan-Mar       Impact factor: 6.543

8.  The role of metallothionein in oxidative stress.

Authors:  Branislav Ruttkay-Nedecky; Lukas Nejdl; Jaromir Gumulec; Ondrej Zitka; Michal Masarik; Tomas Eckschlager; Marie Stiborova; Vojtech Adam; Rene Kizek
Journal:  Int J Mol Sci       Date:  2013-03-15       Impact factor: 5.923
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.