BACKGROUND: Undifferentiated (embryonal) sarcoma of the liver is a rare, highly malignant, mesenchymal tumor presenting predominantly in late childhood. Four girls, ages 6-13 years, who were treated with combined-modality regimens are reported. METHODS: In the first and second patients, hemihepatectomy resulted in complete removal of the tumor, and multiple-agent chemotherapy was administered postoperatively. In the third patient, only partial resection could be accomplished initially. By synchronous radiation therapy and chemotherapy, the tumor decreased to an extent that it could be resected completely and was totally devitalized on histologic examination. Postoperative chemotherapy was discontinued after 8 weeks. In the fourth patient, the tumor was not resectable at diagnostic biopsy. Polychemotherapy led to a significant reduction of the tumor size, and resection with clear margins could be performed subsequently. Because histologic necrosis amounted to about 95%, postoperative chemotherapy was also discontinued after 6 weeks. RESULTS: All four patients remain well without evidence of tumor recurrence after 79, 41, 36, and 22 months from diagnosis. CONCLUSIONS: The authors suggest that a multimodal therapeutic regimen should be used in patients with undifferentiated hepatic sarcoma.
BACKGROUND: Undifferentiated (embryonal) sarcoma of the liver is a rare, highly malignant, mesenchymal tumor presenting predominantly in late childhood. Four girls, ages 6-13 years, who were treated with combined-modality regimens are reported. METHODS: In the first and second patients, hemihepatectomy resulted in complete removal of the tumor, and multiple-agent chemotherapy was administered postoperatively. In the third patient, only partial resection could be accomplished initially. By synchronous radiation therapy and chemotherapy, the tumor decreased to an extent that it could be resected completely and was totally devitalized on histologic examination. Postoperative chemotherapy was discontinued after 8 weeks. In the fourth patient, the tumor was not resectable at diagnostic biopsy. Polychemotherapy led to a significant reduction of the tumor size, and resection with clear margins could be performed subsequently. Because histologic necrosis amounted to about 95%, postoperative chemotherapy was also discontinued after 6 weeks. RESULTS: All four patients remain well without evidence of tumor recurrence after 79, 41, 36, and 22 months from diagnosis. CONCLUSIONS: The authors suggest that a multimodal therapeutic regimen should be used in patients with undifferentiated hepatic sarcoma.
Authors: G Chocarro; M V Amesty; F Hernández; B G Goiboru Chenu; R Ortíz; S Hernández; A Sánchez; M Gámez; M López Santamaría; J A Tovar Journal: Pediatr Surg Int Date: 2013-07-18 Impact factor: 1.827
Authors: Pedro W Baron; Fatenah Majlessipour; Antranik A Bedros; Craig W Zuppan; Ramzi Ben-Youssef; George Yanni; Okechukwu N Ojogho; Waldo Concepcion Journal: J Gastrointest Surg Date: 2007-01 Impact factor: 3.452
Authors: Yan Shi; Yesenia Rojas; Wei Zhang; Elizabeth A Beierle; John J Doski; Melanie Goldfarb; Adam B Goldin; Kenneth W Gow; Monica Langer; Rebecka L Meyers; Jed G Nuchtern; Sanjeev A Vasudevan Journal: Pediatr Blood Cancer Date: 2016-10-26 Impact factor: 3.167
Authors: Aysha Shattaf; Altaf Jamil; Muhammad Faisal Khanani; Muhammad El-Hayek; Mustafa Baroudi; Omar Trad; Muhammad Kashif Ishaqi Journal: Ann Saudi Med Date: 2012 Mar-Apr Impact factor: 1.526