| Literature DB >> 8402192 |
B Arranz1, A Eriksson, E Mellerup, P Plenge, J Marcusson.
Abstract
5-HT1A, 5-HT1D, 5-HT2 binding sites and affinity and 5-HT uptake sites were simultaneously determined in frontal cortex samples from 23 control subjects, aged 16-75 years. A significant reduction in the number of 5-HT1D and 5-HT2 binding sites was found with regard to age, together with a significant decrease in the 5-HT2 binding affinity. It is suggested that the total 5-HT1 age-related loss described in previous studies could be ascribed to the 5-HT2 subtype. Furthermore, aging does not seem to be associated with a reduced cortical serotonergic innervation, as indicated by the stability of the [3H]paroxetine-labeled 5-HT uptake sites.Entities:
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Year: 1993 PMID： 8402192 DOI： 10.1016/0006-8993(93)90286-v
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252