Literature DB >> 8400474

Molecular mechanisms of trauma-induced neuronal degeneration.

S A Lipton1.   

Abstract

Recent studies suggest that various neuron-specific responses, including activation of glutamate receptors, muscarinic receptors, and oxidative stress, contribute to the events leading to brain and spinal cord neuronal degeneration after trauma. These specific mechanisms and possible future treatments are highlighted in this review.

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Year:  1993        PMID： 8400474

Source DB:  PubMed          Journal:  Curr Opin Neurol Neurosurg        ISSN： 0951-7383


  9 in total

Review 1.  Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults.

Authors:  Stuart A Lipton
Journal:  NeuroRx       Date:  2004-01

2.  Chronic mild stress eliminates the neuroprotective effect of Copaxone after CNS injury.

Authors:  Igor Smirnov; James T Walsh; Jonathan Kipnis
Journal:  Brain Behav Immun       Date:  2013-01-04       Impact factor: 7.217

3.  Symptomatic headaches.

Authors:  G Bono; P Merlo; G Sances; F Tancioni; M Mauri
Journal:  Ital J Neurol Sci       Date:  1995-12

4.  Variations in the cerebrospinal fluid proteome following traumatic brain injury and subarachnoid hemorrhage.

Authors:  David E Connor; Ganta V Chaitanya; Prashant Chittiboina; Paul McCarthy; L Keith Scott; Lisa Schrott; Alireza Minagar; Anil Nanda; J Steven Alexander
Journal:  Pathophysiology       Date:  2017-05-13

5.  Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.

Authors:  Cara A Mosley; Scott J Myers; Ernest E Murray; Rose Santangelo; Yesim A Tahirovic; Natalie Kurtkaya; Praseeda Mullasseril; Hongjie Yuan; Polina Lyuboslavsky; Phuong Le; Lawrence J Wilson; Manuel Yepes; Ray Dingledine; Stephen F Traynelis; Dennis C Liotta
Journal:  Bioorg Med Chem       Date:  2009-07-05       Impact factor: 3.641

Review 6.  Mechanical and cellular processes driving cervical myelopathy.

Authors:  Roisin T Dolan; Joseph S Butler; John M O'Byrne; Ashley R Poynton
Journal:  World J Orthop       Date:  2016-01-18

7.  CGS 19755 (Selfotel): A Novel Neuroprotective Agent Against CNS Injury.

Authors:  Miguel A Pérez-Pinzón; Gary K Steinberg
Journal:  CNS Drug Rev       Date:  1996-09-01

8.  Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function.

Authors:  Cecily E Hamill; Guido Mannaioni; Polina Lyuboslavsky; Aristide A Sastre; Stephen F Traynelis
Journal:  Exp Neurol       Date:  2009-02-10       Impact factor: 5.330

9.  In vitro P38MAPK inhibition in aged astrocytes decreases reactive astrocytes, inflammation and increases nutritive capacity after oxygen-glucose deprivation.

Authors:  Miren Revuelta; Amaia Elicegui; Till Scheuer; Stefanie Endesfelder; Christoph Bührer; Leire Moreno-Cugnon; Ander Matheu; Thomas Schmitz
Journal:  Aging (Albany NY)       Date:  2021-02-09       Impact factor: 5.682
  9 in total

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