Literature DB >> 8398931

An investigation into the effects of chloroquine on fertility of male rats.

A O Okanlawon1, C C Noronha, O A Ashiru.   

Abstract

We investigated the effect of chloroquine on the fertility of adult male rats. Rats were administered chloroquine at a daily intra-peritoneal dose of 10mg/kg body weight and 40mg/kg body weight per rat, five days a week for 16 weeks. Females mated with treated males showed a dose dependent decrease in the number of litter per female rat. In the in-vitro studies, more than 80% os spermatozoa were immotile in all concentrations of chloroquine tested. These results suggest that chloroquine brings about its antifertility effect by decreasing sperm motility.

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Year:  1993        PMID： 8398931

Source DB:  PubMed          Journal:  West Afr J Med        ISSN： 0189-160X


  5 in total

1.  Diet-induced obesity impairs spermatogenesis: a potential role for autophagy.

Authors:  Yang Mu; Wen-Jie Yan; Tai-Lang Yin; Yan Zhang; Jie Li; Jing Yang
Journal:  Sci Rep       Date:  2017-03-09       Impact factor: 4.379

2.  Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.

Authors:  Silvia Rizzi; Maarten J Wensink; Rune Lindahl-Jacobsen; Lu Tian; Ying Lu; Michael L Eisenberg
Journal:  BMC Res Notes       Date:  2020-11-07

Review 3.  An Update on the Relationship of SARS-CoV-2 and Male Reproduction.

Authors:  Juncen Guo; Kai Sheng; Sixian Wu; Hanxiao Chen; Wenming Xu
Journal:  Front Endocrinol (Lausanne)       Date:  2021-11-23       Impact factor: 5.555

4.  Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.

Authors:  Silvia Rizzi; Maarten Jan Wensink; Rune Lindahl-Jacobsen; Lu Tian; Ying Lu; Michael Eisenberg
Journal:  Res Sq       Date:  2020-08-26

5.  Chloroquine commonly induces hormetic dose responses.

Authors:  Edward J Calabrese; Jaap C Hanekamp; Yannic N Hanekamp; Rachna Kapoor; Gaurav Dhawan; Evgenios Agathokleous
Journal:  Sci Total Environ       Date:  2020-09-25       Impact factor: 7.963
  5 in total

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