Literature DB >> 8398155

The C. elegans unc-18 gene encodes a protein expressed in motor neurons.

K Gengyo-Ando1, Y Kamiya, A Yamakawa, K Kodaira, K Nishiwaki, J Miwa, I Hori, R Hosono.   

Abstract

The C. elegans unc-18 gene is required to maintain normal acetylcholine levels. We determined the complete structure of an unc-18 cDNA that encodes a protein of 591 highly charged and hydrophilic amino acids. The protein shows sequence similarity with elements of the secretory pathway in the yeast S. cerevisiae. Antibodies raised against a portion of the unc-18-encoded protein (UNC-18) detected a 68 kd soluble antigen on immunoblots and intensely stained all vertical cord motor neurons in situ. These findings suggest that UNC-18 participates in the axonal transport system and influences the acetylcholine flow in motor neurons.

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Year:  1993        PMID： 8398155     DOI： 10.1016/0896-6273(93)90080-b

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  31 in total

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4.  Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ.

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5.  A neuronal Sec1 homolog regulates neurotransmitter release at the squid giant synapse.

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6.  Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants.

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Journal:  J Neurosci       Date:  1998-01-01       Impact factor: 6.167

7.  A genetic selection for Caenorhabditis elegans synaptic transmission mutants.

Authors:  K G Miller; A Alfonso; M Nguyen; J A Crowell; C D Johnson; J B Rand
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8.  Defects in synaptic vesicle docking in unc-18 mutants.

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Review 9.  Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders.

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Journal:  Mol Neurobiol       Date:  2013-03-14       Impact factor: 5.590

10.  Charting the secretory pathway in a simple eukaryote.

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Journal:  Mol Biol Cell       Date:  2010-11-15       Impact factor: 4.138
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