Literature DB >> 8397765

The use of monoclonal antibodies to achieve immunological tolerance.

H Waldmann1, S Cobbold.   

Abstract

Monoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms.

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Year:  1993        PMID： 8397765     DOI： 10.1016/0167-5699(93)90040-R

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  8 in total

Review 1.  Dominant regulation: a common mechanism of monoclonal antibody induced tolerance?

Authors:  K Honey; S P Cobbold; H Waldmann
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

Review 2.  Prospects for induction of tolerance in renal transplantation.

Authors:  A M Krensky; C Clayberger
Journal:  Pediatr Nephrol       Date:  1994-12       Impact factor: 3.714

Review 3.  Immunosuppressive therapy for chronic uveitis: optimising therapy with steroids and cyclosporin A.

Authors:  A D Dick; M Azim; J V Forrester
Journal:  Br J Ophthalmol       Date:  1997-12       Impact factor: 4.638

Review 4.  Immunologic tolerance in renal transplantation.

Authors:  D A Shoskes
Journal:  World J Urol       Date:  1996       Impact factor: 4.226

Review 5.  Experimental approaches to specific immunotherapies in autoimmune disease: future treatment of endogenous posterior uveitis?

Authors:  A D Dick
Journal:  Br J Ophthalmol       Date:  1995-01       Impact factor: 4.638

6.  The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands.

Authors:  J Madrenas; L A Chau; J Smith; J A Bluestone; R N Germain
Journal:  J Exp Med       Date:  1997-01-20       Impact factor: 14.307

7.  Th1/Th2 cytokines and ICAM-1 levels post-liver transplant do not predict early rejection.

Authors:  E Granot; A Tarcsafalvi; S Emre; P Sheiner; S Guy; M E Schwartz; P Boros; C M Miller
Journal:  Mediators Inflamm       Date:  2000       Impact factor: 4.711

8.  Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts.

Authors:  K Yamada; P R Gianello; F L Ierino; T Lorf; A Shimizu; S Meehan; R B Colvin; D H Sachs
Journal:  J Exp Med       Date:  1997-08-18       Impact factor: 14.307
  8 in total

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