Literature DB >> 8397261

Nonoxynol-9 protects mice against vaginal transmission of genital herpes infections.

K J Whaley1, R A Barratt, L Zeitlin, T E Hoen, R A Cone.   

Abstract

A vaginal application of a commercially available contraceptive jelly containing nonoxynol-9 (N9) prevented vaginal transmission of herpes simplex virus type 2 (HSV-2) infections in the mouse. When N9 jelly was delivered to the vagina with the virus inoculum, 20 s before inoculum, or 5 min before inoculum, mice were completely protected from visible infection (P < .001). Protection lasted for at least 30 min (P < .03), and significant protection occurred even when the N9 jelly was delivered 15 min after the HSV-2 inoculum (P < .05). These results are consistent with results of studies using N9 products in other animal models and suggest that N9-based contraceptive products can provide significant protection against vaginal transmission of enveloped virus infections in animals.

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Year:  1993        PMID： 8397261     DOI： 10.1093/infdis/168.4.1009

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  8 in total

1.  Thermoreversible gel formulations containing sodium lauryl sulfate or n-Lauroylsarcosine as potential topical microbicides against sexually transmitted diseases.

Authors:  S Roy; P Gourde; J Piret; A Désormeaux; J Lamontagne; C Haineault; R F Omar; M G Bergeron
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

2.  Vaginal formulations of carrageenan protect mice from herpes simplex virus infection.

Authors:  V R Zacharopoulos; D M Phillips
Journal:  Clin Diagn Lab Immunol       Date:  1997-07

3.  Bile salts: natural detergents for the prevention of sexually transmitted diseases.

Authors:  B C Herold; R Kirkpatrick; D Marcellino; A Travelstead; V Pilipenko; H Krasa; J Bremer; L J Dong; M D Cooper
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

4.  High resolution imaging of epithelial injury in the sheep cervicovaginal tract: a promising model for testing safety of candidate microbicides.

Authors:  Kathleen L Vincent; Nigel Bourne; Brent A Bell; Gracie Vargas; Alai Tan; Daniel Cowan; Lawrence R Stanberry; Susan L Rosenthal; Massoud Motamedi
Journal:  Sex Transm Dis       Date:  2009-05       Impact factor: 2.830

5.  Use of high-resolution confocal imaging of the vaginal epithelial microstructure to detect microbicide toxicity.

Authors:  Gracie Vargas; Tuya Shilagard; Rebecca Johnston; Brent Bell; Rachael L Stegall; Kathleen Vincent; Lawrence Stanberry; Massoud Motamedi; Nigel Bourne
Journal:  J Infect Dis       Date:  2009-05-15       Impact factor: 5.226

6.  The synergistic effect of IFN-alpha and IFN-gamma against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin.

Authors:  Erina Petrera; Celia E Coto
Journal:  Virol J       Date:  2006-06-13       Impact factor: 4.099

7.  Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission.

Authors:  Richard A Cone; Timothy Hoen; Xixi Wong; Raed Abusuwwa; Deborah J Anderson; Thomas R Moench
Journal:  BMC Infect Dis       Date:  2006-06-01       Impact factor: 3.090

8.  Medroxyprogesterone acetate and levonorgestrel increase genital mucosal permeability and enhance susceptibility to genital herpes simplex virus type 2 infection.

Authors:  N E Quispe Calla; R D Vicetti Miguel; P N Boyaka; L Hall-Stoodley; B Kaur; W Trout; S D Pavelko; T L Cherpes
Journal:  Mucosal Immunol       Date:  2016-03-23       Impact factor: 7.313
  8 in total

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