Literature DB >> 8397094

Cloning and functional expression of a human parathyroid hormone receptor.

H Schneider1, J H Feyen, K Seuwen, N R Movva.   

Abstract

We have cloned a human receptor for parathyroid hormone from a kidney complementary DNA library. The deduced sequence of 593 amino acids shows high homology to the previously cloned receptors from opossum and rat. Expressed in COS-1 cells, the human receptor binds to parathyroid hormone-(1-38) with high affinity (pKD = 8.5) and is functionally coupled to adenylate cyclase (pEC50 = 9.4). At high concentrations of agonist, the receptor also activates phosphoinositide turnover.

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Year:  1993        PMID： 8397094     DOI： 10.1016/0922-4106(93)90092-n

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

1.  Signaling by N- and C-terminal sequences of parathyroid hormone-related protein in hippocampal neurons.

Authors:  S Fukayama; A H Tashjian; J N Davis; J C Chisholm
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-24       Impact factor: 11.205

2.  Parathyroid hormone/parathyroid hormone related peptide receptor gene transcripts are expressed from tissue-specific and ubiquitous promoters.

Authors:  K A McCuaig; H S Lee; J C Clarke; H Assar; J Horsford; J H White
Journal:  Nucleic Acids Res       Date:  1995-06-11       Impact factor: 16.971

3.  Heparin-insensitive calcium release from intracellular stores triggered by the recombinant human parathyroid hormone receptor.

Authors:  K Seuwen; H G Boddeke
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

4.  Molecular cloning and functional characterization of the canine parathyroid hormone/parathyroid hormone related peptide receptor (PTH1).

Authors:  S L Smock; G A Vogt; T A Castleberry; B Lu; T A Owen
Journal:  Mol Biol Rep       Date:  2001       Impact factor: 2.316

5.  Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken.

Authors:  Pedro L C Pinheiro; João C R Cardoso; Deborah M Power; Adelino V M Canário
Journal:  BMC Evol Biol       Date:  2012-07-06       Impact factor: 3.260
  5 in total

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