Literature DB >> 8396931

Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor.

A Hirasawa1, K Horie, T Tanaka, K Takagaki, M Murai, J Yano, G Tsujimoto.   

Abstract

We have cloned human alpha 1C-adrenergic receptor from human prostate cDNA library. The deduced amino acid sequence of the clone (P2C4) encodes a protein of 466 amino acids that showed strong sequence homology to the previously cloned bovine alpha 1C-adrenergic receptor. The radioligand binding properties of P2C4 expressed in COS-7 cells were very similar to those of bovine alpha 1C-adrenergic receptor. With reverse-transcription polymerase chain reaction assay, we observed alpha 1C-adrenergic receptor transcripts in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. The data show that the clone P2C4 encodes a human alpha 1C-adrenergic receptor cDNA, and the receptor subtype is expressed not widely but localized in several human tissues.

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Year:  1993        PMID： 8396931     DOI： 10.1006/bbrc.1993.2130

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

1.  Distribution of alpha-1 adrenoceptor subtypes in RNA and protein in rabbit eyes.

Authors:  Fumiko Suzuki; Takanobu Taniguchi; Seigo Nakamura; Yoshio Akagi; Chikara Kubota; Makoto Satoh; Ikunobu Muramatsu
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

2.  Effects of castration on contraction and alpha(1)-adrenoceptor expression in rat prostate.

Authors:  Y Homma; K Hamada; Y Nakayama; G Tsujimoto; K Kawabe
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

3.  Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice.

Authors:  Chihiro Hosoda; Akito Tanoue; Mari Shibano; Yoshio Tanaka; Masami Hiroyama; Taka-aki Koshimizu; Susanna Cotecchia; Tadaichi Kitamura; Gozoh Tsujimoto; Katsuo Koike
Journal:  Br J Pharmacol       Date:  2005-10       Impact factor: 8.739

4.  Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C.

Authors:  C L Barr; K Wigg; G Zai; W Roberts; M Malone; R Schachar; R Tannock; J L Kennedy
Journal:  Mol Psychiatry       Date:  2001-05       Impact factor: 15.992

5.  The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction.

Authors:  Akito Tanoue; Yoshihisa Nasa; Takaaki Koshimizu; Hitomi Shinoura; Sayuri Oshikawa; Takayuki Kawai; Sachie Sunada; Satoshi Takeo; Gozoh Tsujimoto
Journal:  J Clin Invest       Date:  2002-03       Impact factor: 14.808

6.  Quantification and distribution of alpha 1-adrenoceptor subtype mRNAs in human prostate: comparison of benign hypertrophied tissue and non-hypertrophied tissue.

Authors:  K Nasu; N Moriyama; K Kawabe; G Tsujimoto; M Murai; T Tanaka; J Yano
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

7.  Activation of tyrosine kinases by alpha1A-adrenergic and growth factor receptors in transfected PC12 cells.

Authors:  H Zhong; K P Minneman
Journal:  Biochem J       Date:  1999-12-15       Impact factor: 3.857

Review 8.  Classification of alpha 1-adrenoceptor subtypes.

Authors:  M C Michel; B Kenny; D A Schwinn
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-07       Impact factor: 3.000

9.  Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy.

Authors:  K Shibata; A Hirasawa; N Moriyama; K Kawabe; S Ogawa; G Tsujimoto
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739

10.  Selectivity of the imidazoline alpha-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned alpha 1-adrenoceptor subtypes.

Authors:  K Horie; K Obika; R Foglar; G Tsujimoto
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739
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