Literature DB >> 8396687

Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes.

K R Berend1, J U Jung, T J Boyle, J M DiMaio, S A Mungal, R C Desrosiers, H K Lyerly.   

Abstract

Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

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Year:  1993        PMID： 8396687      PMCID： PMC238060     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  15 in total

1.  Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation.

Authors:  S C Murthy; J J Trimble; R C Desrosiers
Journal:  J Virol       Date:  1989-08       Impact factor: 5.103

2.  Classification of herpesvirus saimiri into three groups based on extreme variation in a DNA region required for oncogenicity.

Authors:  P Medveczky; E Szomolanyi; R C Desrosiers; C Mulder
Journal:  J Virol       Date:  1984-12       Impact factor: 5.103

3.  Deletion of DNA sequence in a nononcogenic variant of Herpesvirus saimiri.

Authors:  J M Koomey; C Mulder; R L Burghoff; B Fleckenstein; R C Desrosiers
Journal:  J Virol       Date:  1984-05       Impact factor: 5.103

4.  A region of the Herpesvirus saimiri genome required for oncogenicity.

Authors:  R C Desrosiers; A Bakker; J Kamine; L A Falk; R D Hunt; N W King
Journal:  Science       Date:  1985-04-12       Impact factor: 47.728

5.  Nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalization.

Authors:  R C Desrosiers; D P Silva; L M Waldron; N L Letvin
Journal:  J Virol       Date:  1986-02       Impact factor: 5.103

6.  Herpesvirus saimiri strains from three DNA subgroups have different oncogenic potentials in New Zealand white rabbits.

Authors:  M M Medveczky; E Szomolanyi; R Hesselton; D DeGrand; P Geck; P G Medveczky
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

7.  Expression of interleukin 2 receptors in T cells transformed by strains of Herpesvirus saimiri representing three DNA subgroups.

Authors:  P G Medveczky; M M Medveczky
Journal:  Intervirology       Date:  1989       Impact factor: 1.763

8.  Herpesvirus saimiri strain variability.

Authors:  R C Desrosiers; L A Falk
Journal:  J Virol       Date:  1982-07       Impact factor: 5.103

9.  Stable growth transformation of human T lymphocytes by herpesvirus saimiri.

Authors:  B Biesinger; I Müller-Fleckenstein; B Simmer; G Lang; S Wittmann; E Platzer; R C Desrosiers; B Fleckenstein
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

10.  Herpesvirus saimiri strain 11 immortalizes a restricted marmoset T8 lymphocyte subpopulation in vitro.

Authors:  M Kiyotaki; R C Desrosiers; N L Letvin
Journal:  J Exp Med       Date:  1986-09-01       Impact factor: 14.307
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  11 in total

1.  The Herpesvirus Saimiri open reading frame 73 gene product interacts with the cellular protein p32.

Authors:  Kersten T Hall; Mathew S Giles; Michael A Calderwood; Delyth J Goodwin; David A Matthews; Adrian Whitehouse
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

2.  Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus Saimiri.

Authors:  H Fickenscher; C Bökel; A Knappe; B Biesinger; E Meinl; B Fleischer; B Fleckenstein; B M Bröker
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

3.  Substitution of ras for the herpesvirus saimiri STP oncogene in lymphocyte transformation.

Authors:  J Guo; K Williams; S M Duboise; L Alexander; R Veazey; J U Jung
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

Review 4.  Herpesvirus saimiri.

Authors:  H Fickenscher; B Fleckenstein
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-04-29       Impact factor: 6.237

5.  Analysis of gene expression in a human cell line stably transduced with herpesvirus saimiri.

Authors:  K T Hall; M S Giles; D J Goodwin; M A Calderwood; I M Carr; A J Stevenson; A F Markham; A Whitehouse
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

6.  Association of the viral oncoprotein STP-C488 with cellular ras.

Authors:  J U Jung; R C Desrosiers
Journal:  Mol Cell Biol       Date:  1995-12       Impact factor: 4.272

7.  STP and Tip are essential for herpesvirus saimiri oncogenicity.

Authors:  S M Duboise; J Guo; S Czajak; R C Desrosiers; J U Jung
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

8.  Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes.

Authors:  H Fickenscher; B Biesinger; A Knappe; S Wittmann; B Fleckenstein
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

9.  A role for herpesvirus saimiri orf14 in transformation and persistent infection.

Authors:  M Duboise; J Guo; S Czajak; H Lee; R Veazey; R C Desrosiers; J U Jung
Journal:  J Virol       Date:  1998-08       Impact factor: 5.103

10.  Immortalization of human T cells expressing T-cell receptor gamma delta by herpesvirus saimiri.

Authors:  M Yasukawa; Y Inoue; N Kimura; S Fujita
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103
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