Literature DB >> 8396647

A cluster of strong topoisomerase II cleavage sites is located near an integrated human immunodeficiency virus.

M T Howard1, J D Griffith.   

Abstract

The Human Immunodeficiency Virus (HIV) integrates into host cellular DNA as a double strand DNA molecule. Here a previously studied HIV isolate was examined for binding and cleavage by topoisomerase II in vitro within the 5' LTR region and human flanking DNA. A cluster of strong binding and cleavage sites in the human sequences was located approximately 850 bp upstream from the integration site. This region maps to a locus consisting of a complex repeating element, and alternating purine/pyrimidine sequences. Topoisomerase II binding and cleavage sites were also located within the HIV 5' LTR, in particular a site overlying the DNA sequence coding for TAR, another inverted repeat element in the DNA.

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Year:  1993        PMID： 8396647     DOI： 10.1006/jmbi.1993.1460

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  9 in total

1.  Chromosome structure and human immunodeficiency virus type 1 cDNA integration: centromeric alphoid repeats are a disfavored target.

Authors:  S Carteau; C Hoffmann; F Bushman
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

2.  A nuclear matrix-specific factor that binds a specific segment of the negative regulatory element (NRE) of HIV-1 LTR and inhibits NF-kappa(B) activity.

Authors:  T Hoover; J Mikovits; D Court; Y L Liu; H F Kung
Journal:  Nucleic Acids Res       Date:  1996-05-15       Impact factor: 16.971

3.  Distribution of topoisomerase II-mediated cleavage sites and relation to structural and functional landmarks in 830 kb of Drosophila DNA.

Authors:  R Miassod; S V Razin; R Hancock
Journal:  Nucleic Acids Res       Date:  1997-06-01       Impact factor: 16.971

4.  Photoelectron imaging of viruses and DNA: evaluation of substrates by unidirectional low angle shadowing and photoemission current measurements.

Authors:  G B Birrell; D L Habliston; O H Griffith
Journal:  Biophys J       Date:  1994-11       Impact factor: 4.033

5.  Host sequences flanking the human T-cell leukemia virus type 1 provirus in vivo.

Authors:  I Leclercq; F Mortreux; M Cavrois; A Leroy; A Gessain; S Wain-Hobson; E Wattel
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

6.  Stimulation of Tat-independent transcriptional processivity from the HIV-1 LTR promoter by matrix attachment regions.

Authors:  Shravanti Rampalli; Asavari Kulkarni; Pavan Kumar; Devraj Mogare; Sanjeev Galande; Debashis Mitra; Samit Chattopadhyay
Journal:  Nucleic Acids Res       Date:  2003-06-15       Impact factor: 16.971

7.  Human immunodeficiency virus type 1 may preferentially integrate into chromatin occupied by L1Hs repetitive elements.

Authors:  S W Stevens; J D Griffith
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

8.  On the general theory of the origins of retroviruses.

Authors:  Misaki Wayengera
Journal:  Theor Biol Med Model       Date:  2010-02-16       Impact factor: 2.432

Review 9.  Models for chromosomal replication-independent non-B DNA structure-induced genetic instability.

Authors:  Guliang Wang; Karen M Vasquez
Journal:  Mol Carcinog       Date:  2009-04       Impact factor: 4.784
  9 in total

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