Literature DB >> 8396461

The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus.

E Castrén1, M Pitkänen, J Sirviö, A Parsadanian, D Lindholm, H Thoenen, P J Riekkinen.   

Abstract

We have investigated the expression of the mRNAs for brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) in the hippocampus before and after induction of long term potentiation (LTP) of synaptic transmission in the dentate gyrus through stimulation of the perforant path (PP). A unilateral PP stimulation produced a bilateral increase in the mRNA for both BDNF and NGF in granular neurones of the dentate gyrus but not in other neurones in the hippocampus. The mRNA for neurotrophin-3 (NT-3) was bilaterally decreased by LTP but that of NT-4 remained at the basal level. These results suggest that individual neurotrophic factors may play different roles in neuronal plasticity.

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Year:  1993        PMID： 8396461     DOI： 10.1097/00001756-199307000-00014

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  71 in total

1.  Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus.

Authors:  W A Gottschalk; H Jiang; N Tartaglia; L Feng; A Figurov; B Lu
Journal:  Learn Mem       Date:  1999 May-Jun       Impact factor: 2.460

2.  Ultrastructural localization of full-length trkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity.

Authors:  C T Drake; T A Milner; S L Patterson
Journal:  J Neurosci       Date:  1999-09-15       Impact factor: 6.167

3.  Brain-derived neurotrophic factor enhances long-term potentiation in rat visual cortex.

Authors:  Y Akaneya; T Tsumoto; S Kinoshita; H Hatanaka
Journal:  J Neurosci       Date:  1997-09-01       Impact factor: 6.167

4.  Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus.

Authors:  Sridhara Chakravarthy; M Hadi Saiepour; Matthew Bence; Sean Perry; Robin Hartman; Jonathan J Couey; Huibert D Mansvelder; Christiaan N Levelt
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-17       Impact factor: 11.205

Review 5.  The influences of diet and exercise on mental health through hormesis.

Authors:  Fernando Gomez-Pinilla
Journal:  Ageing Res Rev       Date:  2007-05-05       Impact factor: 10.895

6.  Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.

Authors:  M Korte; O Griesbeck; C Gravel; P Carroll; V Staiger; H Thoenen; T Bonhoeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

7.  A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction.

Authors:  Oswald Steward; Fen Huang; John F Guzowski
Journal:  Learn Mem       Date:  2007-06-11       Impact factor: 2.460

8.  Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors.

Authors:  E S Levine; C F Dreyfus; I B Black; M R Plummer
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

Review 9.  Exercise and brain health--implications for multiple sclerosis: Part 1--neuronal growth factors.

Authors:  Lesley J White; Vanessa Castellano
Journal:  Sports Med       Date:  2008       Impact factor: 11.136

10.  Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity.

Authors:  E S Levine; R A Crozier; I B Black; M R Plummer
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205
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