| Literature DB >> 8395021 |
P J McLaughlin1, J T Gooch, H G Mannherz, A G Weeds.
Abstract
The structure of the segment 1 domain of gelsolin, a protein that fragments actin filaments in cells, is reported in complex with actin. Segment 1 binds monomer using an apolar patch rimmed by hydrogen bonds in a cleft between actin domains. On the actin filament model it binds tangentially, disrupting only those contacts between adjacent subunits in one helical strand. The segment 1 fold is general for all segments of the gelsolin family because the conserved residues form the core of the structure. It also provides a basis for understanding the origin of an amyloidosis caused by a gelsolin variant.Entities:
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Year: 1993 PMID： 8395021 DOI： 10.1038/364685a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962