Literature DB >> 8394948

[Establishment and characterization of a new human testicular germ cell tumor cell line (TCam-2)].

Y Mizuno1, A Gotoh, S Kamidono, S Kitazawa.   

Abstract

A new human testicular cancer cell line (TCam-2) was established. The original material of TCam-2 was a primary lesion of a left testicular seminoma (typical pure type seminoma) from a 35 aged male patient. TCam-2 produced neither AFP nor beta-HCG, It showed strong immunoreactivities for 5G9 (anti testicular cancer MoAb), 4B3 (anti PTHrP MoAb) and PALP (placental alkaline phosphatase). The chromosomal analysis revealed 92 modal number and loss of Y chromosome. Histochemical, morphological and chromosomal analysis supported that TCam-2 is from classical seminoma. TCam-2 was transplanted subcutaneously to the back of 6 weeks old scid mice (CB-17 strain), and grew a classical seminomatous tissue.

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Mesh：

Year:  1993        PMID： 8394948     DOI： 10.5980/jpnjurol1989.84.1211

Source DB:  PubMed          Journal:  Nihon Hinyokika Gakkai Zasshi        ISSN： 0021-5287


  39 in total

1.  Protruding disordered loop of gC1qR is specifically exposed and related to antiapoptotic property in germ cell lineage.

Authors:  Sohei Kitazawa; Atsushi Takenaka; Takeshi Kondo; Akira Mizoguchi; Riko Kitazawa
Journal:  Histochem Cell Biol       Date:  2006-07-27       Impact factor: 4.304

2.  In vitro study on shRNA-mediated reduction of testis developmental related gene 1 expression and its effects on the proliferation, invasion and apoptosis of NTERA-2 cells.

Authors:  Y U Gan; Jianfu Yang; Yong Wang; Zhengyu Tan; Xianzhen Jiang; Yuxin Tang
Journal:  Oncol Lett       Date:  2015-05-18       Impact factor: 2.967

3.  TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway.

Authors:  Yu Gan; Yong Wang; Zhengyu Tan; Jun Zhou; Riko Kitazawa; Xianzhen Jiang; Yuxin Tang; Jianfu Yang
Journal:  Cancer Biol Ther       Date:  2016-04-22       Impact factor: 4.742

4.  Zika virus infects human testicular tissue and germ cells.

Authors:  Giulia Matusali; Laurent Houzet; Anne-Pascale Satie; Dominique Mahé; Florence Aubry; Thérèse Couderc; Julie Frouard; Salomé Bourgeau; Karim Bensalah; Sylvain Lavoué; Guillaume Joguet; Louis Bujan; André Cabié; Gleide Avelar; Marc Lecuit; Anna Le Tortorec; Nathalie Dejucq-Rainsford
Journal:  J Clin Invest       Date:  2018-07-31       Impact factor: 14.808

5.  Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ cell tumors in vitro and in vivo.

Authors:  Martin Blomberg Jensen; Anne Jørgensen; John Erik Nielsen; Andreas Steinmeyer; Henrik Leffers; Anders Juul; Ewa Rajpert-De Meyts
Journal:  Neoplasia       Date:  2012-10       Impact factor: 5.715

6.  Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1.

Authors:  Sarah M Russell; Melissa G Lechner; Anusuya Mokashi; Carolina Megiel; Julie K Jang; Clive R Taylor; Leendert H J Looijenga; Christopher A French; Alan L Epstein
Journal:  Urology       Date:  2013-02       Impact factor: 2.649

7.  Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition.

Authors:  Monalisa F Azevedo; Anelia Horvath; Ethan R Bornstein; Madson Q Almeida; Paraskevi Xekouki; Fabio R Faucz; Evgenia Gourgari; Kiran Nadella; Elaine F Remmers; Martha Quezado; Rodrigo Bertollo de Alexandre; Christian P Kratz; Maria Nesterova; Mark H Greene; Constantine A Stratakis
Journal:  J Clin Endocrinol Metab       Date:  2013-06-14       Impact factor: 5.958

Review 8.  Cancer stem cells as targets for cancer therapy: selected cancers as examples.

Authors:  Sabine Hombach-Klonisch; Ted Paranjothy; Emilia Wiechec; Paola Pocar; Tarek Mustafa; Anja Seifert; Christian Zahl; Klaus Luis Gerlach; Katharina Biermann; Klaus Steger; Cuong Hoang-Vu; Klaus Schulze-Osthoff; Marek Los
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2008-05-30       Impact factor: 4.291

9.  [Molecular pathology of testicular germ cell tumors: an update].

Authors:  K Biermann; H Zhou; R Büttner
Journal:  Pathologe       Date:  2008-09       Impact factor: 1.011

10.  Monoclonal antibody (5F3) defining renal cell carcinoma-associated antigen disialosyl globopentaosylceramide (V3NeuAcIV6NeuAcGb5), and distribution pattern of the antigen in tumor and normal tissues.

Authors:  A Ito; S Saito; T Masuko; M Oh-Eda; T Matsuura; M Satoh; F M Nejad; T Enomoto; S Orikasa; S I Hakomori
Journal:  Glycoconj J       Date:  2001-06       Impact factor: 2.916
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