Literature DB >> 8394834

Molecular cloning and expression of a cDNA encoding a receptor for pituitary adenylate cyclase activating polypeptide (PACAP).

J A Morrow1, E M Lutz, K M West, G Fink, A J Harmar.   

Abstract

We have cloned and sequenced a novel cDNA (RPR7) encoding a receptor for pituitary adenylate cyclase activating polypeptide (PACAP). RPR7 was identified by PCR of rat pituitary cDNA, and full-length clones were isolated from a rat olfactory bulb cDNA library. When expressed in COS cells, RPR7 was functionally coupled to increases in intracellular cyclic adenosine monophosphate (cAMP) in response to stimulation by PACAP-38, PACAP-27, vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). The order of potency of these ligands was PACAP-38-PACAP-27 > VIP > PHI, suggesting that the receptor corresponds to the pharmacologically characterised PACAP Type I receptor.

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Year:  1993        PMID： 8394834     DOI： 10.1016/0014-5793(93)80202-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Domains determining agonist selectivity in chimaeric VIP2 (VPAC2)/PACAP (PAC1) receptors.

Authors:  E M Lutz; C J MacKenzie; M Johnson; K West; J A Morrow; A J Harmar; R Mitchell
Journal:  Br J Pharmacol       Date:  1999-10       Impact factor: 8.739

2.  Identification of endogenous sympathetic neuron pituitary adenylate cyclase-activating polypeptide (PACAP): depolarization regulates production and secretion through induction of multiple propeptide transcripts.

Authors:  C A Brandenburg; V May; K M Braas
Journal:  J Neurosci       Date:  1997-06-01       Impact factor: 6.167

3.  Specific antibody recognition of rat pituitary adenylate cyclase activating polypeptide receptors.

Authors:  M Li; S Shioda; A Somogyvári-Vigh; H Onda; A Arimura
Journal:  Endocrine       Date:  1997-10       Impact factor: 3.633

Review 4.  Neuropeptides of the pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide/growth hormone-releasing hormone/secretin family in testis.

Authors:  Min Li; Akira Arimura
Journal:  Endocrine       Date:  2003-04       Impact factor: 3.633

5.  Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells.

Authors:  N Inagaki; H Yoshida; M Mizuta; N Mizuno; Y Fujii; T Gonoi; J Miyazaki; S Seino
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-29       Impact factor: 11.205

6.  Pituitary adenylate cyclase-activating polypeptide, helospectin, and vasoactive intestinal polypeptide in human corpus cavernosum.

Authors:  P Hedlund; P Alm; P Ekström; J Fahrenkrug; J Hannibal; H Hedlund; B Larsson; K E Andersson
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

Review 7.  Advent and recent advances in research on the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of gonadotropic hormone secretion of female rats.

Authors:  Katalin Köves; Orsolya Kántor; András Lakatos; Enikő Szabó; Eszter Kirilly; Andrea Heinzlmann; Flóra Szabó
Journal:  J Mol Neurosci       Date:  2014-04-03       Impact factor: 3.444

Review 8.  International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide.

Authors:  A J Harmar; A Arimura; I Gozes; L Journot; M Laburthe; J R Pisegna; S R Rawlings; P Robberecht; S I Said; S P Sreedharan; S A Wank; J A Waschek
Journal:  Pharmacol Rev       Date:  1998-06       Impact factor: 25.468

9.  Agnathan VIP, PACAP and their receptors: ancestral origins of today's highly diversified forms.

Authors:  Stephanie Y L Ng; Billy K C Chow; Jun Kasamatsu; Masanori Kasahara; Leo T O Lee
Journal:  PLoS One       Date:  2012-09-05       Impact factor: 3.240

Review 10.  Discovery of PACAP and its receptors in the brain.

Authors:  Takahiro Hirabayashi; Tomoya Nakamachi; Seiji Shioda
Journal:  J Headache Pain       Date:  2018-04-04       Impact factor: 7.277
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