| Literature DB >> 8394832 |
Y Iwata1, H Nakamura, Y Mizuno, M Yoshida, E Ozawa, M Shigekawa.
Abstract
In ventricular muscle from 30- to 60-day-old Bio 14.6 cardiomyopathic hamsters, dystrophin-associated glycoproteins of 43, 50 and 150 kDa are markedly reduced in abundance. In particular, the 50-kDa glycoprotein is totally deficient in the sarcolemma of myopathic ventricular myocytes as revealed by immunofluorescence microscopy. The dystrophin-glycoprotein complex formation is defective in the cardiomyopathic hamster heart, because dystrophin and the glycoproteins behave independently when digitonin-solubilized ventricular homogenates are fractionated on wheat germ agglutinin beads or anti-dystrophin immunoaffinity beads.Entities:
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Year: 1993 PMID: 8394832 DOI: 10.1016/0014-5793(93)80227-l
Source DB: PubMed Journal: FEBS Lett ISSN: 0014-5793 Impact factor: 4.124