| Literature DB >> 8394751 |
O Rosnet1, C Schiff, M J Pébusque, S Marchetto, C Tonnelle, Y Toiron, F Birg, D Birnbaum.
Abstract
The human FLT3 cDNA was cloned from a pre-B cell line and characterized. The deduced amino acid sequence shows that FLT3 codes for a receptor-type tyrosine kinase of 993 residues, presenting a strong similarity with the corresponding mouse FLT3/FLK2 protein as well as with the receptors for colony-stimulating factor 1 (CSF1R/FMS) and steel locus factor (SLFR/KIT). An analysis of the expression of the gene using amplification of reverse transcribed FLT3 mRNA by polymerase chain reaction shows that FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin.Entities:
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Year: 1993 PMID： 8394751
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113