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Literature DB >> 8394730

Molecular alterations in a patient with Turcot's syndrome.

C F Rochlitz¹, I Heide, E de Kant, A Neubauer, C A Schmidt, P Neuhaus, D Huhn, R Herrmann.

Abstract

Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents.

Entities: Disease Gene Species

Mesh：

Year: 1993 PMID： 8394730 PMCID： PMC1968408 DOI： 10.1038/bjc.1993.379

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

24 in total

1. Malignant tumors of the central nervous system associated with familial polyposis of the colon: report of two cases.

Authors: J TURCOT; J P DESPRES; F ST PIERRE
Journal: Dis Colon Rectum Date: 1959 Sep-Oct Impact factor: 4.585

2. Detection of amplified oncogenes by differential polymerase chain reaction.

Authors: R A Frye; C C Benz; E Liu
Journal: Oncogene Date: 1989-09 Impact factor: 9.867

3. Polymerase chain reaction based assay to detect allelic loss in human DNA: loss of beta-interferon gene in chronic myelogenous leukemia.

Authors: A Neubauer; B Neubauer; E Liu
Journal: Nucleic Acids Res Date: 1990-02-25 Impact factor: 16.971

Molecular alterations in a patient with Turcot's syndrome.

1. Malignant tumors of the central nervous system associated with familial polyposis of the colon: report of two cases.

2. Detection of amplified oncogenes by differential polymerase chain reaction.

3. Polymerase chain reaction based assay to detect allelic loss in human DNA: loss of beta-interferon gene in chronic myelogenous leukemia.

4. Amplification of a highly polymorphic VNTR segment by the polymerase chain reaction.

5. Genetic alterations during colorectal-tumor development.

6. Turcot's syndrome. Evidence for autosomal dominant inheritance.

7. Identification of a chromosome 18q gene that is altered in colorectal cancers.

8. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas.

9. Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer.

10. Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1. Expression and mutational analysis of Nm23-H1 in liver metastases of colorectal cancer.