Literature DB >> 8394723

Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide.

H Hashimoto1, T Ishihara, R Shigemoto, K Mori, S Nagata.   

Abstract

Pituitary adenylate cyclase-activating polypeptide (PA-CAP) is a polypeptide hormone related to vasoactive intestinal polypeptide (VIP). Rat PACAP receptor cDNA was isolated from a brain cDNA library by cross-hybridization with rat VIP receptor cDNA. The recombinant PACAP receptor expressed in COS cells bound PACAP with about 1000 times higher affinity than VIP, and PACAP stimulated adenylate cyclase through the cloned PACAP receptor. The rat PACAP receptor consists of 495 amino acids, contains seven transmembrane segments, and has a significant similarity with other Gs-coupled receptors, such as VIP, glucagon, and secretin receptors. PACAP receptor mRNA was abundantly expressed in the brain, but not in the peripheral tissues except for the adrenal gland. In situ hybridization revealed a high level of expression of PACAP receptor mRNA in the hippocampal dentate gyrus, olfactory bulb, and cerebellar cortex.

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Year:  1993        PMID： 8394723     DOI： 10.1016/0896-6273(93)90188-w

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  37 in total

1.  Pituitary adenylyl cyclase-activating polypeptide stimulates DNA synthesis but delays maturation of oligodendrocyte progenitors.

Authors:  M Lee; V Lelievre; P Zhao; M Torres; W Rodriguez; J Y Byun; S Doshi; Y Ioffe; G Gupta; A E de los Monteros; J de Vellis; J Waschek
Journal:  J Neurosci       Date:  2001-06-01       Impact factor: 6.167

2.  Domains determining agonist selectivity in chimaeric VIP2 (VPAC2)/PACAP (PAC1) receptors.

Authors:  E M Lutz; C J MacKenzie; M Johnson; K West; J A Morrow; A J Harmar; R Mitchell
Journal:  Br J Pharmacol       Date:  1999-10       Impact factor: 8.739

3.  Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP.

Authors:  H Cadas; S Gaillet; M Beltramo; L Venance; D Piomelli
Journal:  J Neurosci       Date:  1996-06-15       Impact factor: 6.167

4.  Peptidergic activation of transcription and secretion in chromaffin cells. Cis and trans signaling determinants of pituitary adenylyl cyclase-activating polypeptide (PACAP).

Authors:  L Taupenot; S K Mahata; H Wu; D T O'Connor
Journal:  J Clin Invest       Date:  1998-02-15       Impact factor: 14.808

5.  Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit.

Authors:  Jun-Hyeong Cho; Ko Zushida; Gleb P Shumyatsky; William A Carlezon; Edward G Meloni; Vadim Y Bolshakov
Journal:  J Neurosci       Date:  2012-10-10       Impact factor: 6.167

6.  Pituitary adenylate cyclase-activating polypeptide expression and modulation of neuronal excitability in guinea pig cardiac ganglia.

Authors:  K M Braas; V May; S A Harakall; J C Hardwick; R L Parsons
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

7.  Pituitary adenylate cyclase-activating polypeptide stimulates glucose production via the hepatic sympathetic innervation in rats.

Authors:  Chun-Xia Yi; Ning Sun; Mariette T Ackermans; Anneke Alkemade; Ewout Foppen; Jing Shi; Mireille J Serlie; Ruud M Buijs; Eric Fliers; Andries Kalsbeek
Journal:  Diabetes       Date:  2010-03-31       Impact factor: 9.461

Review 8.  Neuropeptides of the pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide/growth hormone-releasing hormone/secretin family in testis.

Authors:  Min Li; Akira Arimura
Journal:  Endocrine       Date:  2003-04       Impact factor: 3.633

9.  Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations.

Authors:  Kohei Yamada; Shinsuke Matsuzaki; Tsuyoshi Hattori; Ryusuke Kuwahara; Manabu Taniguchi; Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba; Natsuko Kumamoto; Kazuo Yamada; Takeo Yoshikawa; Taiichi Katayama; Masaya Tohyama
Journal:  PLoS One       Date:  2010-01-06       Impact factor: 3.240

10.  Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival.

Authors:  Victor May; Eve Lutz; Christopher MacKenzie; Kristin C Schutz; Kate Dozark; Karen M Braas
Journal:  J Biol Chem       Date:  2010-01-21       Impact factor: 5.157
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