Literature DB >> 8394245

Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes.

K Fukuda1, S Kato, K Mori, M Nishi, H Takeshima.   

Abstract

The complete amino acid sequences of rat opioid receptors (designated as ROR-A and ROR-B) have been deduced by cloning and sequencing the cDNAs. The ligand-binding properties of ROR-A and ROR-B expressed from the cloned cDNAs in Chinese hamster ovary cells correspond most closely to those of the pharmacologically defined delta- and mu-opioid receptor subtypes, respectively. RNA blot hybridization analysis revealed that cerebrum and brainstem contain both ROR-A and ROR-B mRNAs, whereas neither ROR-A nor ROR-B mRNAs can be detected in cerebellum.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8394245     DOI： 10.1016/0014-5793(93)81011-n

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  37 in total

1.  Characterization of the decrease of extracellular striatal dopamine induced by intrastriatal morphine administration.

Authors:  T P Piepponen; J A Mikkola; M Ruotsalainen; D Jonker; L Ahtee
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

2.  Differentiation of delta, mu, and kappa opioid receptor agonists based on pharmacophore development and computed physicochemical properties.

Authors:  M Filizola; H O Villar; G H Loew
Journal:  J Comput Aided Mol Des       Date:  2001-04       Impact factor: 3.686

3.  Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution.

Authors:  M G Darlison; F R Greten; R J Harvey; H J Kreienkamp; T Stühmer; H Zwiers; K Lederis; D Richter
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

Review 4.  Post-transcriptional regulation of opioid receptors in the nervous system.

Authors:  Li-Na Wei; Ping-Yee Law; Horace H Loh
Journal:  Front Biosci       Date:  2004-05-01

Review 5.  In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands.

Authors:  Richard A Houghten; Colette T Dooley; Jon R Appel
Journal:  AAPS J       Date:  2006-05-26       Impact factor: 4.009

6.  A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist.

Authors:  Nidhi Singh; Gwénaël Chevé; David M Ferguson; Christopher R McCurdy
Journal:  J Comput Aided Mol Des       Date:  2006-09-29       Impact factor: 3.686

7.  Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists.

Authors:  P A Claude; D R Wotta; X H Zhang; P L Prather; T M McGinn; L J Erickson; H H Loh; P Y Law
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

8.  Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors.

Authors:  H Higashida; N Hoshi; R Knijnik; J E Zadina; A J Kastin
Journal:  J Physiol       Date:  1998-02-15       Impact factor: 5.182

9.  Bioinformatic analysis of the human mu opioid receptor (OPRM1) splice and polymorphic variants.

Authors:  Lili Xin; Zaijie Jim Wang
Journal:  AAPS PharmSci       Date:  2002

Review 10.  Modulation of pain transmission by G-protein-coupled receptors.

Authors:  Hui-Lin Pan; Zi-Zhen Wu; Hong-Yi Zhou; Shao-Rui Chen; Hong-Mei Zhang; De-Pei Li
Journal:  Pharmacol Ther       Date:  2007-09-22       Impact factor: 12.310
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.