Literature DB >> 839414

Identification of nonpolar methotrimeprazine metabolites in plasma and urine by GLC-mass spectrometry.

S G Dahl, M Garle.   

Abstract

Two metabolites of methotrimeprazine, the sulfoxide and the demethylated analog, were identified in extracts from patient plasma by combined GLC-mass spectrometry. Methotrimeprazine and its sulfoxide had similar mass spectra but different GLC retention times. In addition to the metabolites found in plasma, two other metabolites, the didesmethyl analog and the monodesmethyl sulfoxide, were identified in a urine extract.

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Year:  1977        PMID： 839414     DOI： 10.1002/jps.2600660214

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  4 in total

1.  Region specific distribution of levomepromazine in the human brain.

Authors:  J Kornhuber; H Weigmann; J Röhrich; J Wiltfang; S Bleich; I Meineke; R Zöchling; S Härtter; P Riederer; C Hiemke
Journal:  J Neural Transm (Vienna)       Date:  2005-07-06       Impact factor: 3.575

2.  Binding affinity of levomepromazine and two of its major metabolites of central dopamine and alpha-adrenergic receptors in the rat.

Authors:  S G Dahl; H Hall
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

3.  Anti-apomorphine effects of phenothiazine drug metabolites.

Authors:  E Morel; K G Lloyd; S G Dahl
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

4.  Metabolism of levomepromazine in man.

Authors:  P A Hals; S G Dahl
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1995 Jan-Mar       Impact factor: 2.441
  4 in total

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