Literature DB >> 8393669

Bovine chromaffin cells possess FTX-sensitive calcium channels.

L Gandía1, A Albillos, A G García.   

Abstract

The effects of the synthetic analogue of the toxin from the venom of the funnel-web spider Agenelopsis aperta (sFTX) on whole-cell Ba2+ currents through Ca2+ channels were studied in cultured bovine chromaffin cells. sFTX selectively and reversibly blocked a significant component (55 +/- 3%) of the whole-cell IBa. Effects of sFTX were additive to those of omega-conotoxin GVIA, a selective blocker of N-type Ca2+ channels, and those of furnidipine, a novel dihydropyridine L-type Ca2+ channel blocker. We conclude that the cultured bovine chromaffin cells, in addition to N- and L-type Ca2+ channels, possess a P-type component in their whole-cell currents through their Ca2+ channels.

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Year:  1993        PMID： 8393669     DOI： 10.1006/bbrc.1993.1874

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

1.  R-Type Ca2+ channels are coupled to the rapid component of secretion in mouse adrenal slice chromaffin cells.

Authors:  A Albillos; E Neher; T Moser
Journal:  J Neurosci       Date:  2000-11-15       Impact factor: 6.167

2.  Drastic facilitation by alpha-latrotoxin of bovine chromaffin cell exocytosis without measurable enhancement of Ca2+ entry or [Ca2+]i.

Authors:  P Michelena; M T de la Fuente; T Vega; B Lara; M G López; L Gandía; A G García
Journal:  J Physiol       Date:  1997-08-01       Impact factor: 5.182

3.  Voltage-activated Ca(2+) channels and their role in the endocrine function of the pituitary gland in newborn and adult mice.

Authors:  Simon Sedej; Tetsuhiro Tsujimoto; Robert Zorec; Marjan Rupnik
Journal:  J Physiol       Date:  2004-01-14       Impact factor: 5.182

4.  Inhibition of N and PQ calcium channels by calcium entry through L channels in chromaffin cells.

Authors:  Juliana M Rosa; Luis Gandía; Antonio G García
Journal:  Pflugers Arch       Date:  2009-04-04       Impact factor: 3.657

Review 5.  Regulation by L-type calcium channels of endocytosis: an overview.

Authors:  Juliana M Rosa; Carmen Nanclares; Angela Orozco; Inés Colmena; Ricardo de Pascual; Antonio G García; Luis Gandía
Journal:  J Mol Neurosci       Date:  2012-05-12       Impact factor: 3.444

6.  Low threshold T-type calcium current in rat embryonic chromaffin cells.

Authors:  R Bournaud; J Hidalgo; H Yu; E Jaimovich; T Shimahara
Journal:  J Physiol       Date:  2001-11-15       Impact factor: 5.182

Review 7.  L-type calcium channels in exocytosis and endocytosis of chromaffin cells.

Authors:  Carmen Nanclares; Andrés M Baraibar; Luis Gandía
Journal:  Pflugers Arch       Date:  2017-09-02       Impact factor: 3.657

8.  Re-evaluation of the P/Q Ca2+ channel components of Ba2+ currents in bovine chromaffin cells superfused with solutions containing low and high Ba2+ concentrations.

Authors:  A Albillos; A G García; B Olivera; L Gandía
Journal:  Pflugers Arch       Date:  1996-10       Impact factor: 3.657

9.  Multiple calcium channel subtypes in isolated rat chromaffin cells.

Authors:  L Gandía; R Borges; A Albillos; A G García
Journal:  Pflugers Arch       Date:  1995-05       Impact factor: 3.657

10.  Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by diltiazem.

Authors:  L Gandía; M Villarroya; F Sala; J A Reig; S Viniegra; J L Quintanar; A G García; L M Gutiérrez
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739
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