Literature DB >> 8393300

Antisense technology: biological utility and practical considerations.

L Neckers1, L Whitesell.   

Abstract

Antisense RNA and DNA techniques have been developed as a relatively recent approach to the specific modulation of gene expression in vitro and in vivo. This review discusses general considerations for the application of antisense techniques. We shall examine the relative advantages and disadvantages of DNA versus RNA techniques, as well as the common pitfalls peculiar to each strategy.

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Year:  1993        PMID: 8393300     DOI: 10.1152/ajplung.1993.265.1.L1

Source DB:  PubMed          Journal:  Am J Physiol        ISSN: 0002-9513


  6 in total

1.  A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: effects of antisense to the A1 receptor in the cholinergic basal forebrain.

Authors:  Mahesh M Thakkar; Stuart Winston; Robert W McCarley
Journal:  J Neurosci       Date:  2003-05-15       Impact factor: 6.167

Review 2.  Application of antisense DNA method for the study of molecular bases of brain function and behavior.

Authors:  S Ogawa; D W Pfaff
Journal:  Behav Genet       Date:  1996-05       Impact factor: 2.805

3.  Bioavailability of antisense oligonucleotides in neuroblastoma cells: comparison of efficacy among different types of molecules.

Authors:  M V Corrias; F Guarnaccia; M Ponzoni
Journal:  J Neurooncol       Date:  1997-01       Impact factor: 4.130

Review 4.  Brief overview of control of genetic expression by antisense oligonucleotides and in vivo applications. Prospects for neurobiology.

Authors:  G Zon
Journal:  Mol Neurobiol       Date:  1995 Apr-Jun       Impact factor: 5.590

5.  Inhibition of ubiquitous mitochondrial creatine kinase expression in HeLa cells by an antisense oligodeoxynucleotide.

Authors:  N Enjolras; C Godinot
Journal:  Mol Cell Biochem       Date:  1997-02       Impact factor: 3.396

6.  Plasminogen activator inhibitor-1 antisense oligodeoxynucleotides abrogate mesangial fibronectin accumulation.

Authors:  Jehyun Park; Ji Yeon Seo; Hunjoo Ha
Journal:  Korean J Physiol Pharmacol       Date:  2010-12-31       Impact factor: 2.016

  6 in total

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