Literature DB >> 8393116

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.

P L Ornstein1, M B Arnold, N K Augenstein, D Lodge, J D Leander, D D Schoepp.   

Abstract

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8393116     DOI： 10.1021/jm00066a016

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


× No keyword cloud information.
  12 in total

Review 1.  Medicinal chemistry of competitive kainate receptor antagonists.

Authors:  Ann M Larsen; Lennart Bunch
Journal:  ACS Chem Neurosci       Date:  2010-12-10       Impact factor: 4.418

2.  Behavioural and neurochemical interactions of the AMPA antagonist GYKI 52466 and the non-competitive NMDA antagonist dizocilpine in rats.

Authors:  M Bubser; T Tzschentke; W Hauber
Journal:  J Neural Transm Gen Sect       Date:  1995

3.  Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisoquinoline- 3-carboxylic acid (LY293558) and its racemate (LY215490).

Authors:  D D Schoepp; C R Salhoff; K S Fuson; A I Sacaan; J P Tizzano; P L Ornstein; P C May
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

4.  Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors.

Authors:  Anne E Sarver; Aaron L Sarver; Venugopal Thayanithy; Subbaya Subramanian
Journal:  Lab Invest       Date:  2015-06-29       Impact factor: 5.662

5.  Locomotor activity detects subunit-selective effects of agonists and decahydroisoquinoline antagonists at AMPA/kainic acid ionotropic glutamate receptors in adult rats.

Authors:  Michael F O'neill; Graham Sanger; Paul L Ornstein; David J Osborne; Sandra M Woodhouse
Journal:  Psychopharmacology (Berl)       Date:  2005-01-26       Impact factor: 4.530

6.  Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance.

Authors:  Johanna J Bogulavsky; Ann M Gregus; Paul T-H Kim; Alberto C S Costa; Anjali M Rajadhyaksha; Charles E Inturrisi
Journal:  J Pharmacol Exp Ther       Date:  2008-10-28       Impact factor: 4.030

7.  Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein.

Authors:  Zhen Chen; Wakana Mori; Xiaofei Zhang; Tomoteru Yamasaki; Patrick J Dunn; Genwei Zhang; Hualong Fu; Tuo Shao; Yiding Zhang; Akiko Hatori; Longle Ma; Masayuki Fujinaga; Lin Xie; Xiaoyun Deng; Hua Li; Qingzhen Yu; Jian Rong; Lee Josephson; Jun-An Ma; Yihan Shao; Susumu Tomita; Ming-Rong Zhang; Steven H Liang
Journal:  Eur J Med Chem       Date:  2018-08-09       Impact factor: 6.514

Review 8.  AMPA receptors as a molecular target in epilepsy therapy.

Authors:  M A Rogawski
Journal:  Acta Neurol Scand Suppl       Date:  2013

9.  Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors.

Authors:  Jiahui Chen; Jiefeng Gan; Jiyun Sun; Zhen Chen; Hualong Fu; Jian Rong; Xiaoyun Deng; Jingjie Shang; Jian Gong; Tuo Shao; Lee Collier; Lu Wang; Hao Xu; Steven H Liang
Journal:  Tetrahedron Lett       Date:  2020-01-17       Impact factor: 2.415

10.  Radiosynthesis and preliminary PET evaluation of (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors.

Authors:  Gengyang Yuan; Graham B Jones; Neil Vasdev; Steven H Liang
Journal:  Bioorg Med Chem Lett       Date:  2016-08-09       Impact factor: 2.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.