Literature DB >> 8393011

A possible role for Epstein-Barr virus in tumorigenesis after immunosuppression in cases of renal transplantation.

T Suzuki1, Y Takano, K Yamashita, K Sato, A Kakita, M Okudaira.   

Abstract

Eight secondary malignancies developing after renal transplantation were investigated in terms of a possible role of the Epstein-Barr virus (EBV). In five cases, four gastric cancers and one colonic cancer, the presence of EBV was proven by the polymerase chain reaction (PCR), all four gastric lesions being confirmed to have a massive EBV infection by in situ hybridization. Two cases demonstrated monoclonal infection with EBV, as indicated by a single band of the lymphocyte-defined membrane antigen tandem-repeat gene using PCR, and were immunohistochemically positive for the latent membrane protein 1. Our series suggests that gastrointestinal cancer predominates as a secondary malignancy in states of induced severe immunosuppression, and that EBV may play an important role in tumorigenesis as an oncovirus.

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Year:  1993        PMID： 8393011     DOI： 10.1007/bf01372727

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  14 in total

1.  Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells.

Authors:  H Herbst; F Dallenbach; M Hummel; G Niedobitek; S Pileri; N Müller-Lantzsch; H Stein
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

2.  Simplified procedures for applying the polymerase chain reaction to routinely fixed paraffin wax sections.

Authors:  P J Coates; A J d'Ardenne; G Khan; H O Kangro; G Slavin
Journal:  J Clin Pathol       Date:  1991-02       Impact factor: 3.411

3.  Purification of DNA from formaldehyde fixed and paraffin embedded human tissue.

Authors:  S E Goelz; S R Hamilton; B Vogelstein
Journal:  Biochem Biophys Res Commun       Date:  1985-07-16       Impact factor: 3.575

Review 4.  Cancers after cyclosporine therapy.

Authors:  I Penn
Journal:  Transplant Proc       Date:  1988-02       Impact factor: 1.066

5.  Latent and replicating forms of Epstein-Barr virus DNA in lymphomas and lymphoproliferative diseases.

Authors:  B Z Katz; N Raab-Traub; G Miller
Journal:  J Infect Dis       Date:  1989-10       Impact factor: 5.226

6.  Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma.

Authors:  D Shibata; L M Weiss; B N Nathwani; R K Brynes; A M Levine
Journal:  Blood       Date:  1991-04-01       Impact factor: 22.113

7.  Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma.

Authors:  D Shibata; M Tokunaga; Y Uemura; E Sato; S Tanaka; L M Weiss
Journal:  Am J Pathol       Date:  1991-09       Impact factor: 4.307

8.  Detection of Epstein-Barr virus sequences in Hodgkin's disease by the polymerase chain reaction.

Authors:  C F Wright; A H Reid; M M Tsai; K M Ventre; P J Murari; G Frizzera; T J O'Leary
Journal:  Am J Pathol       Date:  1991-08       Impact factor: 4.307

9.  HLA-restricted T-cell recognition of Epstein-Barr virus-infected B cells.

Authors:  A B Rickinson; L E Wallace; M A Epstein
Journal:  Nature       Date:  1980-02-28       Impact factor: 49.962

10.  B-cell lymphoproliferative disorders in solid-organ transplant patients: detection of Epstein-Barr virus by in situ hybridization.

Authors:  L C Berg; C M Copenhaver; V A Morrison; S A Gruber; D L Dunn; K Gajl-Peczalska; J G Strickler
Journal:  Hum Pathol       Date:  1992-02       Impact factor: 3.466
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  1 in total

Review 1.  Infections in solid-organ transplant recipients.

Authors:  R Patel; C V Paya
Journal:  Clin Microbiol Rev       Date:  1997-01       Impact factor: 26.132
  1 in total

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