Literature DB >> 839239

Meningeal carcinomatosis: development of an experimental model.

Y Ushio, N L Chernik, J B Posner, W R Shapiro.   

Abstract

An experimental model of meningeal carcinomatosis has been produced by intracisternal inoculation of Walker 256 carcinoma cell suspension into Wistar rats. The tumor grows rapidly and is fatal in about 15 days if 10(6) cells are injected. The histopathological pattern observed is similar to that seen in diffuse leptomeningeal involvement of systemic cancer in human beings. The model will be useful for investigating the pathophysiology of the neurological disability produced by meningeal carcinomatosis and the efficacy of chemotherapeutic agents.

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Year:  1977        PMID： 839239     DOI： 10.1097/00005072-197703000-00003

Source DB:  PubMed          Journal:  J Neuropathol Exp Neurol        ISSN： 0022-3069            Impact factor:   3.685


  13 in total

1.  A rat model of leptomeningeal human neoplastic xenografts.

Authors:  I Bergman; M Ahdab-Barmada; S S Kemp; J A Griffin; N K Cheung
Journal:  J Neurooncol       Date:  1997-09       Impact factor: 4.130

Review 2.  Animal models of leptomeningeal metastasis.

Authors:  M Schabet; U Herrlinger
Journal:  J Neurooncol       Date:  1998 Jun-Jul       Impact factor: 4.130

3.  Pathology of brain parenchyma in meningeal carcinomatosis; immunohistochemical study with astroprotein (GFAP) and tubulin.

Authors:  J Jamshidi; T Yoshimine; Y Ushio; T Hayakawa; K Morimoto; H Mogami
Journal:  J Neurooncol       Date:  1987       Impact factor: 4.130

4.  A simple mouse model for leptomeningeal metastases and repeated intrathecal therapy.

Authors:  J C Reijneveld; M J Taphoorn; E E Voest
Journal:  J Neurooncol       Date:  1999-04       Impact factor: 4.130

5.  ACNU, MTX and 5-FU penetration of rat brain tissue and tumors.

Authors:  T Y Huang; N Arita; T Hayakawa; Y Ushio
Journal:  J Neurooncol       Date:  1999       Impact factor: 4.130

6.  Pharmacokinetics of intrathecal 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in rats.

Authors:  T Y Huang; N Arita; Y Ushio; T Hayakawa; K Yamada
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

7.  A new rat brain tumor model: glioma disseminated via the cerebral spinal fluid pathways.

Authors:  A B Rewers; E S Redgate; M Deutsch; E R Fisher; S S Boggs
Journal:  J Neurooncol       Date:  1990-06       Impact factor: 4.130

8.  Intrathecal treatment of C6 glioma leptomeningeal metastasis in Wistar rats with interleukin-2.

Authors:  U Herrlinger; R Buchholz; P Jachimczak; M Schabet
Journal:  J Neurooncol       Date:  1996-03       Impact factor: 4.130

9.  Alteration of blood-brain-CSF barrier in experimental meningeal carcinomatosis. A morphologic and adriamycin-penetration study.

Authors:  T Siegal; U Sandbank; A Gabizon; T Siegal; R Mizrachi; E Ben-David; R Catane
Journal:  J Neurooncol       Date:  1987       Impact factor: 4.130

10.  Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.

Authors:  Adrienne Boire; Yilong Zou; Jason Shieh; Danilo G Macalinao; Elena Pentsova; Joan Massagué
Journal:  Cell       Date:  2017-03-09       Impact factor: 41.582
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