Literature DB >> 8392321

Multiple amino acid substitutions in the HN protein of the paramyxovirus, SV5, are selected for in monoclonal antibody resistant mutants.

D U Baty1, R E Randall.   

Abstract

Monoclonal antibody resistant (MAR) mutants (which escaped antibody-mediated neutralization) were selected from simian (W 3) and human (LN) isolates of simian virus 5 (SV 5), using monoclonal antibodies (MAbs) specific for antigenic sites 4 and 5 on the HN glycoprotein. Resistance correlated with an inability of the selecting antibody to bind with the respective MAR mutants. Sequence comparisons between parental and mutant HN proteins revealed multiple non-adjacent amino acid substitutions in the majority of MAR mutants. The same multiple substitutions were identified in mutants selected from both the LN and W 3 isolates of SV 5. Furthermore, different mutations on the primary sequence of the HN protein conferred resistance to the same MAb.

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Year:  1993        PMID： 8392321     DOI： 10.1007/bf01379094

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  18 in total

1.  MULTIPLICATION OF A MYXOVIRUS (SV5) WITH MINIMAL CYTOPATHIC EFFECTS AND WITHOUT INTERFERENCE.

Authors:  P W CHOPPIN
Journal:  Virology       Date:  1964-06       Impact factor: 3.616

2.  Homogeneous distribution of parainfluenza virus glycoproteins demonstrated by immunogold-labelling and light staining with uranyl acetate in electron microscopy.

Authors:  F Hernandez; P Rivera; Y Hosaka
Journal:  J Virol Methods       Date:  1987-03       Impact factor: 2.014

3.  Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein.

Authors:  I Seif; P Coulon; P E Rollin; A Flamand
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

4.  Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor.

Authors:  S W Hiebert; R G Paterson; R A Lamb
Journal:  J Virol       Date:  1985-04       Impact factor: 5.103

Review 5.  The role of viral glycoproteins in adsorption, penetration, and pathogenicity of viruses.

Authors:  P W Choppin; A Scheid
Journal:  Rev Infect Dis       Date:  1980 Jan-Feb

6.  Sequence analysis of the HN gene of parainfluenza virus type 2.

Authors:  B Precious; J A Southern; R E Randall
Journal:  J Gen Virol       Date:  1990-05       Impact factor: 3.891

7.  Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5.

Authors:  D U Baty; J A Southern; R E Randall
Journal:  J Gen Virol       Date:  1991-12       Impact factor: 3.891

8.  A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody.

Authors:  J J Skehel; D J Stevens; R S Daniels; A R Douglas; M Knossow; I A Wilson; D C Wiley
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

9.  Monoclonal antibodies to the HN glycoprotein of Newcastle disease virus. Biological characterization and use for strain comparisons.

Authors:  K Nishikawa; S Isomura; S Suzuki; E Watanabe; M Hamaguchi; T Yoshida; Y Nagai
Journal:  Virology       Date:  1983-10-30       Impact factor: 3.616

10.  Does simian virus 5 infect humans?

Authors:  K K Goswami; L S Lange; D N Mitchell; K R Cameron; W C Russell
Journal:  J Gen Virol       Date:  1984-08       Impact factor: 3.891
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Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

Review 2.  Antivirals targeting paramyxovirus membrane fusion.

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Authors:  R M Iorio; G M Field; J M Sauvron; A M Mirza; R Deng; P J Mahon; J P Langedijk
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

4.  Stability of the parainfluenza virus 5 genome revealed by deep sequencing of strains isolated from different hosts and following passage in cell culture.

Authors:  Bert K Rima; Derek Gatherer; Daniel F Young; Hanna Norsted; Richard E Randall; Andrew J Davison
Journal:  J Virol       Date:  2014-01-22       Impact factor: 5.103

5.  Molecular detection and whole genome characterization of Canine Parainfluenza type 5 in Thailand.

Authors:  Kamonpan Charoenkul; Chanakarn Nasamran; Taveesak Janetanakit; Supassama Chaiyawong; Napawan Bunpapong; Supanat Boonyapisitsopa; Ratanaporn Tangwangvivat; Alongkorn Amonsin
Journal:  Sci Rep       Date:  2021-02-16       Impact factor: 4.379
  5 in total

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