Literature DB >> 8392312

Efficacy of (-)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in African green monkeys infected with simian varicella virus.

K F Soike1, R Bohm, J L Huang, B Oberg.   

Abstract

(-)-9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine was evaluated for its efficacy in African green monkeys infected with simian varicella virus. Treatment by intramuscular injection was initiated 48 h after virus inoculation and was continued for 10 days; the treatment showed therapeutic effects on rash and viremia at dosages down to 1 mg/kg of body weight per day.

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Year:  1993        PMID： 8392312      PMCID： PMC187969          DOI： 10.1128/AAC.37.6.1370

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Evaluation of infrequent dosing regimens with (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine (S-HPMPC) on simian varicella infection in monkeys.

Authors:  K F Soike; J L Huang; J Y Zhang; R Bohm; M J Hitchcock; J C Martin
Journal:  Antiviral Res       Date:  1991-07       Impact factor: 5.970

2.  Inhibiting effect of (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine on varicella-zoster virus replication in cell culture.

Authors:  G Abele; A Karlström; J Harmenberg; S Shigeta; A Larsson; B Lindborg; B Wahren
Journal:  Antimicrob Agents Chemother       Date:  1987-01       Impact factor: 5.191

3.  Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir].

Authors:  R A Vere Hodge; D Sutton; M R Boyd; M R Harnden; R L Jarvest
Journal:  Antimicrob Agents Chemother       Date:  1989-10       Impact factor: 5.191

4.  Inhibition of varicella-zoster virus-induced DNA polymerase by a new guanosine analog, 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine triphosphate.

Authors:  G Abele; B Eriksson; J Harmenberg; B Wahren
Journal:  Antimicrob Agents Chemother       Date:  1988-08       Impact factor: 5.191

5.  Improvement of the absorption of oral (R,S)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine, an anti-varicella-zoster virus drug, in rats and monkeys.

Authors:  D M Lake-Bakaar; B Lindborg; R Datema
Journal:  Antimicrob Agents Chemother       Date:  1989-01       Impact factor: 5.191

6.  Acyclovir in the treatment of simian varicella virus infection of the African green monkey.

Authors:  K F Soike; P J Gerone
Journal:  Am J Med       Date:  1982-07-20       Impact factor: 4.965

7.  The disposition of acyclovir in different species.

Authors:  P de Miranda; H C Krasny; D A Page; G B Elion
Journal:  J Pharmacol Exp Ther       Date:  1981-11       Impact factor: 4.030

8.  Pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys of (R,S)-9-[4-hydroxy-2-(hydroxymethyl) butyl]guanine, an anti-varicella-zoster virus drug.

Authors:  D M Lake-Bakaar; G Abele; B Lindborg; K F Soike; R Datema
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191
  8 in total
  6 in total

1.  Selection and characterization of varicella-zoster virus variants resistant to (R)-9-[4-hydroxy-2-(hydroxymethy)butyl]guanine.

Authors:  T I Ng; Y Shi; H J Huffaker; W Kati; Y Liu; C M Chen; Z Lin; C Maring; W E Kohlbrenner; A Molla
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

Review 2.  Simian varicella in old world monkeys.

Authors:  Wayne L Gray
Journal:  Comp Med       Date:  2008-02       Impact factor: 0.982

Review 3.  Current and potential treatments for ubiquitous but neglected herpesvirus infections.

Authors:  Jonathan E Gable; Timothy M Acker; Charles S Craik
Journal:  Chem Rev       Date:  2014-10-02       Impact factor: 60.622

Review 4.  Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy.

Authors:  Erik De Clercq; Hugh J Field
Journal:  Br J Pharmacol       Date:  2006-01       Impact factor: 8.739

5.  The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil.

Authors:  J Neyts; G Andrei; E De Clercq
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191

6.  Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses.

Authors:  D M Lowe; W K Alderton; M R Ellis; V Parmar; W H Miller; G B Roberts; J A Fyfe; R Gaillard; P Ertl; W Snowden
Journal:  Antimicrob Agents Chemother       Date:  1995-08       Impact factor: 5.191
  6 in total

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