| Literature DB >> 8392298 |
A S Brown1, A G Mallinger, L C Renbaum.
Abstract
Membrane phospholipids were measured in platelets of seven medication-free patients in the manic phase of bipolar affective disorder and seven healthy comparison subjects. The relative percentage of platelet membrane phosphatidylinositol-4,5-bisphosphate was significantly higher in the manic patients than in the comparison subjects. These results are consistent with an enhanced neuronal second messenger response after 5-hydroxytryptamine receptor stimulation followed by neurotransmitter release.Entities:
Mesh：
Substances：
Year: 1993 PMID： 8392298 DOI： 10.1176/ajp.150.8.1252
Source DB: PubMed Journal: Am J Psychiatry ISSN： 0002-953X Impact factor: 18.112