Behavioral effects of opioid peptide agonists DAMGO, DPDPE, and DAKLI on locomotor activities.

The effects of the mu-selective agonist DAMGO (ICV doses of 0.00, 0.01, 0.1, or 1.0 micrograms), the delta-selective agonist DPDPE (ICV doses of 0.00, 0.1, 1.0, or 10.0 micrograms), and the kappa-selective agonist DAKLI (ICV doses of 0.00, 0.01, 0.1, or 1.0 micrograms) were tested in rats for 60 min in an activity monitor. The durations in seconds of linear locomotor time, rearing time, stereotypy time, and margin time (thigmotaxis) were measured during six 10-min time blocks. DAMGO (0.1 and 1.0 micrograms) resulted in biphasic effects, inhibition followed by hyperactivity for linear locomotor, rearing, and stereotypy times, and an inhibition of thigmotaxis. DPDPE (10.0 micrograms) was associated with monophasic potentiation of linear locomotor activity and mixed effects in stereotypy times. DAKLI did not effect horizontal, rearing, or margin times; only stereotypy times resulted in mixed effects of DAKLI. The differential behavioral profiles were discussed in reference to the three opioid receptor subtypes.