Literature DB >> 8391990

Expression of synaptotagmin and syntaxin associated with N-type calcium channels in small cell lung cancer.

P David1, O el Far, N Martin-Mouto, M F Poupon, M Takahashi, M J Seagar.   

Abstract

The presence of synaptic proteins involved in excitation/secretion coupling was examined in ten small cell lung cancer lines. N-Type calcium channels (omega-conotoxin receptors), synaptotagmin (p65) and syntaxin (HPC-1) were detected in eight. Co-immunoprecipitation experiments indicated that syntaxin can form a complex with synaptotagmin and calcium channels. The expression of synaptotagmin in small cell lung cancer may elicit an autoimmune response that reduces transmitter release at the nerve terminal.

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Year:  1993        PMID： 8391990     DOI： 10.1016/0014-5793(93)81777-w

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Mouse VAP33 is associated with the endoplasmic reticulum and microtubules.

Authors:  P A Skehel; R Fabian-Fine; E R Kandel
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

Review 2.  Presynaptic frequency- and pattern-dependent filtering.

Authors:  Alex M Thomson
Journal:  J Comput Neurosci       Date:  2003 Sep-Oct       Impact factor: 1.621

Review 3.  Mechanisms of storage and exocytosis in neuroendocrine tumors.

Authors:  Manfred Gratzl; Martin Breckner; Christian Prinz
Journal:  Endocr Pathol       Date:  2004       Impact factor: 3.943

Review 4.  Metabolism and trafficking of N-type voltage-operated calcium channels in neurosecretory cells.

Authors:  E Sher; P Rosa; M Francolini; A Codignola; E Morlacchi; E Taverna; F Giovannini; A Brioschi; F Clementi; M W McEnery; M Passafaro
Journal:  J Bioenerg Biomembr       Date:  1998-08       Impact factor: 2.945

5.  Interaction of the synprint site of N-type Ca2+ channels with the C2B domain of synaptotagmin I.

Authors:  Z H Sheng; C T Yokoyama; W A Catterall
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

Review 6.  Secretory vesicle pools and rate and kinetics of single vesicle exocytosis in neurosecretory cells.

Authors:  J M Trifaró; M Glavinovic; S D Rosé
Journal:  Neurochem Res       Date:  1997-07       Impact factor: 3.996

Review 7.  Immunopathology of the Lambert-Eaton myasthenic syndrome.

Authors:  B Lang; J Newsom-Davis
Journal:  Springer Semin Immunopathol       Date:  1995

Review 8.  Neuromuscular Active Zone Structure and Function in Healthy and Lambert-Eaton Myasthenic Syndrome States.

Authors:  Scott P Ginebaugh; Yomna Badawi; Tyler B Tarr; Stephen D Meriney
Journal:  Biomolecules       Date:  2022-05-24
  8 in total

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