Literature DB >> 8391883

The clinical significance of regional variations in histologic differentiation within carcinomas of the colorectum.

H Kotanagi1, T Fukuoka, Y Shibata, T Yoshioka, O Aizawa, K Koyama.   

Abstract

The clinical significance of the presence or absence of regional variations in histologic differentiation within a primary colorectal carcinoma was investigated in this study. Regional variations in histologic differentiation were judged to be present when the low power field of a microscope was occupied by cancer tissue cytologically and architecturally different from that of the surrounding area. Regional variations in histologic differentiation were noted in 153 (42%) of 368 primary carcinomas. Carcinomas with regional variations were of an anaplastic histologic type and had a higher incidence of lymph node metastasis and a worse prognosis than those without regional variations. Thus, the histologic diversity within a carcinoma is thought to be important for determining the prognosis of patients with colorectal cancer.

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Year:  1993        PMID： 8391883     DOI： 10.1007/bf00309498

Source DB:  PubMed          Journal:  Surg Today        ISSN： 0941-1291            Impact factor:   2.549


  27 in total

1.  Cell cycle responses of heterogeneous human colon adenocarcinoma subpopulations to X-irradiation.

Authors:  S F Bliven; T E Schneiderman; J T Leith
Journal:  Cell Tissue Kinet       Date:  1987-09

2.  Intratumoral regional differences in DNA ploidy of gastrointestinal carcinomas.

Authors:  K Sasaki; T Hashimoto; K Kawachino; M Takahashi
Journal:  Cancer       Date:  1988-12-15       Impact factor: 6.860

3.  General rules for clinical and pathological studies on cancer of the colon, rectum and anus. Part I. Clinical classification. Japanese Research Society for Cancer of the Colon and Rectum.

Authors: 
Journal:  Jpn J Surg       Date:  1983-11

Review 4.  Heterogeneity of human colon carcinoma.

Authors:  M G Brattain; A E Levine; S Chakrabarty; L C Yeoman; J K Willson; B Long
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

5.  The relative prognostic value of flow cytometric DNA analysis and conventional clinicopathologic criteria in patients with operable rectal carcinoma.

Authors:  N A Scott; L M Rainwater; H S Wieand; L H Weiland; J H Pemberton; R W Beart; M M Lieber
Journal:  Dis Colon Rectum       Date:  1987-07       Impact factor: 4.585

6.  Characteristics of colorectal carcinoma cells with high metastatic potential.

Authors:  R S Bresalier; C R Boland; Y S Kim
Journal:  Gastroenterology       Date:  1984-07       Impact factor: 22.682

7.  The prognostic significance of specific histologic features of carcinoma of the colon and rectum.

Authors:  A de Mascarel; J M Coindre; I de Mascarel; M Trojani; D Marée; B Hoerni
Journal:  Surg Gynecol Obstet       Date:  1981-10

8.  Characterization of two metastatic subpopulations originating from a single human colon carcinoma.

Authors:  E N Spremulli; C Scott; D E Campbell; N P Libbey; D Shochat; D V Gold; D L Dexter
Journal:  Cancer Res       Date:  1983-08       Impact factor: 12.701

9.  DNA stemline heterogeneity in colorectal cancer.

Authors:  W Hiddemann; D B Von Bassewitz; H J Kleinemeier; E Schulte-Brochterbeck; J Hauss; B Lingemann; T Büchner; E Grundmann
Journal:  Cancer       Date:  1986-07-15       Impact factor: 6.860

10.  Is heterogeneous expression of HLA-dr antigens and CEA along with DNA-profile variations evidence of phenotypic instability and clonal proliferation in human large bowel carcinomas?

Authors:  T O Rognum; P Brandtzaeg; E Thorud
Journal:  Br J Cancer       Date:  1983-10       Impact factor: 7.640
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