Literature DB >> 8391451

Cyclic AMP analogues increase excitability and enhance epileptiform activity in rat neocortex in vitro.

C L Boulton1, C R McCrohan, C T O'Shaughnessy.   

Abstract

Effects of the cyclic AMP agonists 8-(4-chlorophenylthio)-adenosine 3':5' cyclic monophosphate (CPT-cAMP), dibutyryl cyclic AMP (dbcAMP) and forskolin were studied on extracellular field potentials in rat neocortex slices in vitro. CPT-cAMP and forskolin produced a prolonged enhancement of epileptiform activity resulting from removal of Mg2+ from the bathing medium. DbcAMP had no apparent effect except at high concentrations (1 mM), when it reduced bursting activity. Field potentials observed following electrical stimulation of the corpus callosum in the presence of Mg2+ were enhanced by CPT-cAMP and dbcAMP; however forskolin was without effect. Intracellular recording techniques demonstrated a transient excitatory influence of dbcAMP. The results indicate a role for cyclic AMP in seizure mechanisms.

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Year:  1993        PMID： 8391451     DOI： 10.1016/0014-2999(93)90235-a

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

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4.  Alcohol Withdrawal Increases Protein Kinase A Activity in the Rat Inferior Colliculus.

Authors:  Luli R Akinfiresoye; Clive Miranda; David M Lovinger; Prosper N'Gouemo
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5.  Cross-modulation of synaptic plasticity by beta-adrenergic and 5-HT1A receptors in the rat basolateral amygdala.

Authors:  S J Wang; L L Cheng; P W Gean
Journal:  J Neurosci       Date:  1999-01-15       Impact factor: 6.167

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7.  Corticotropin-releasing factor facilitates epileptiform activity in the entorhinal cortex: roles of CRF2 receptors and PKA pathway.

Authors:  Lalitha Kurada; Chuanxiu Yang; Saobo Lei
Journal:  PLoS One       Date:  2014-02-04       Impact factor: 3.240

8.  Long-term in vivo application of a potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus.

Authors:  P Kleis; E Paschen; U Häussler; Y A Bernal Sierra; C A Haas
Journal:  BMC Biol       Date:  2022-01-14       Impact factor: 7.431

9.  The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities.

Authors:  Yanke Zhang; Baobing Gao; Fangshuo Zheng; Shanshan Lu; Yun Li; Yan Xiong; Qin Yang; Yong Yang; Pengfei Fu; Fei Xiao; Xuefeng Wang
Journal:  Front Mol Neurosci       Date:  2017-04-07       Impact factor: 5.639
  9 in total

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