Literature DB >> 8391324

Molecular cloning and expression of a rat cDNA encoding MDCK-type chloride channel.

T Abe1, K Takeuchi, K Ishii, K Abe.   

Abstract

A cDNA encoding MDCK-type chloride channel was cloned from the rat kidney cDNA library using the homology screening approach. The deduced amino acid sequence of cloned cDNA has a 92.4% homology with the MDCK chloride channel, and electrophysiological analysis using Xenopus oocyte expression system showed the functional character of chloride channel. The rat kidney chloride channel, abbreviated RKCL, is not specific to the kidney, but widely expressed in various tissues. It is suggested that RKCL is important for most cells.

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Year:  1993        PMID： 8391324     DOI： 10.1016/0167-4781(93)90138-4

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  3 in total

1.  The chloride current induced by expression of the protein pICln in Xenopus oocytes differs from the endogenous volume-sensitive chloride current.

Authors:  T Voets; G Buyse; J Tytgat; G Droogmans; J Eggermont; B Nilius
Journal:  J Physiol       Date:  1996-09-01       Impact factor: 5.182

2.  Single-channel properties of a volume-sensitive anion conductance. Current activation occurs by abrupt switching of closed channels to an open state.

Authors:  P S Jackson; K Strange
Journal:  J Gen Physiol       Date:  1995-05       Impact factor: 4.086

Review 3.  The list of potential volume-sensitive chloride currents continues to swell (and shrink).

Authors:  D E Clapham
Journal:  J Gen Physiol       Date:  1998-05       Impact factor: 4.086
  3 in total

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