| Literature DB >> 839086 |
W L Morison, B S Paul, J A Parrish.
Abstract
Indomethacin, a known inhibitor of prostaglandin synthesis, administered topically as a 2.5% solution, intradermally in 10 mug doses, and orally in a dose of 150 mg/day for 2 days did not diminish the delayed erythema produced a long-wave ultraviolet light (320-400 nm). The delayed phototoxic erythema produced by 8-methoxypsoralen and subsequent exposure the long-wave ultraviolet light was similarly unaffected. By comparison, topical and intradermal indomethacin treatment produced sustained decrease in the erythemal response to ultraviolet radiation in the UVB ranges (290-320 nm).Entities:
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Year: 1977 PMID： 839086 DOI： 10.1111/1523-1747.ep12492445
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551