Literature DB >> 8390800

Estrogen metabolism and human papillomavirus-induced tumors of the larynx: chemo-prophylaxis with indole-3-carbinol.

L Newfield1, A Goldsmith, H L Bradlow, K Auborn.   

Abstract

A relationship was established between estradiol 16 alpha-hydroxylation, papillomavirus and its malignant sequelae. In this study, we determined that 16 alpha-hydroxylation was substantial in normal larynx and further increased in laryngeal papillomas. Estradiol or 16 alpha-hydroxyestrone stimulated proliferation in both kinds of cells while 2-hydroxyestrone was antiproliferative. Indole-3-carbinol, which induces 2-hydroxylation, abrogated the proliferative effects of estradiol. In immunocompromised mice, papilloma cysts formed in HPV-11 infected laryngeal tissue implanted under the renal capsules in 100% of control mice but only in 25% of mice fed indole-3-carbinol.

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Year:  1993        PMID： 8390800

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  9 in total

1.  Recurrent respiratory pappillomatosis: national registry.

Authors:  Anupam Mishra; D B Singh; Veerendra Verma
Journal:  Indian J Otolaryngol Head Neck Surg       Date:  2012-03-29

2.  Pharyngeal squamous cell papilloma in adult Japanese: comparison with laryngeal papilloma in clinical manifestations and HPV infection.

Authors:  Ryoji Hirai; Kiyoshi Makiyama; Yusho Higuti; Atsuo Ikeda; Masatoshi Miura; Hisashi Hasegawa; Noriko Kinukawa; Minoru Ikeda
Journal:  Eur Arch Otorhinolaryngol       Date:  2012-01-04       Impact factor: 2.503

Review 3.  [Current therapeutic options for recurrent respiratory papillomatosis].

Authors:  K Huber; H Sadick; K Götte
Journal:  HNO       Date:  2005-11       Impact factor: 1.284

Review 4.  Indole-3-carbinol as a chemopreventive and anti-cancer agent.

Authors:  Jing-Ru Weng; Chen-Hsun Tsai; Samuel K Kulp; Ching-Shih Chen
Journal:  Cancer Lett       Date:  2008-03-07       Impact factor: 8.679

5.  A controlled safety study of diindolylmethane in the immature rat model.

Authors:  Alphi P Elackattu; Lining Feng; Zhi Wang
Journal:  Laryngoscope       Date:  2009-09       Impact factor: 3.325

6.  The anti-estrogenic activity of indole-3-carbinol in neonatal rat osteoblasts is associated with the estrogen receptor antagonist 2-hydroxyestradiol.

Authors:  J Enríquez; R Velázquez-Cruz; A Parra-Torres; R Gutiérrez-Sagal; F Larrea
Journal:  J Endocrinol Invest       Date:  2016-06-16       Impact factor: 4.256

Review 7.  Current and future management of recurrent respiratory papillomatosis.

Authors:  Ryan Ivancic; Hassan Iqbal; Brad deSilva; Quintin Pan; Laura Matrka
Journal:  Laryngoscope Investig Otolaryngol       Date:  2018-01-14

8.  Sex differences in patients with high risk HPV-associated and HPV negative oropharyngeal and oral cavity squamous cell carcinomas.

Authors:  Hong Li; Henry S Park; Heather A Osborn; Benjamin L Judson
Journal:  Cancers Head Neck       Date:  2018-06-20

9.  Indole-3-carbinol inhibits nasopharyngeal carcinoma cell growth in vivo and in vitro through inhibition of the PI3K/Akt pathway.

Authors:  Cheng-Gang Mao; Ze-Zhang Tao; Zhe Chen; Chen Chen; Shi-Ming Chen; Li-Jia Wan
Journal:  Exp Ther Med       Date:  2014-04-25       Impact factor: 2.447
  9 in total

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