Literature DB >> 8390248

Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors.

S Shiono1, K Kawamoto, N Yoshida, T Kondo, T Inagami.   

Abstract

The significance of phospholipase D in metabolic regulation is being recognized. The products of phospholipase D action are phosphatidic acid and lysophosphatidic acid (LPA). Whether these lipid products exert their effect through plasma membrane receptor-mediated mechanism is not yet clear. In the present study we have shown the presence of specific receptors for LPA in plasma membranes of PC12 pheochromocytoma cells. LPA evoked a transient rise in [Ca2+]i concomitant with formation of IP3. LPA also stimulated dopamine release from PC12 cells. These results indicate that LPA stimulates catecholamine release via specific LPA receptors presumably by activating the IP3 mediated Ca2+ release.

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Year:  1993        PMID： 8390248     DOI： 10.1006/bbrc.1993.1676

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

1.  Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation.

Authors:  K W Young; R A Challiss; S R Nahorski; J J MacKrill
Journal:  Biochem J       Date:  1999-10-01       Impact factor: 3.857

2.  Lysophosphatidic acid induces inositol phosphate and calcium signals in exocrine cells from the avian nasal salt gland.

Authors:  J P Hildebrandt
Journal:  J Membr Biol       Date:  1995-03       Impact factor: 1.843

3.  Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism.

Authors:  K S Ha; E J Yeo; J H Exton
Journal:  Biochem J       Date:  1994-10-01       Impact factor: 3.857

4.  Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1.

Authors:  S Eréndira Avendaño-Vázquez; Agustín García-Caballero; J Adolfo García-Sáinz
Journal:  Biochem J       Date:  2005-02-01       Impact factor: 3.857

5.  Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis.

Authors:  K Jalink; T Hengeveld; S Mulder; F R Postma; M F Simon; H Chap; G A van der Marel; J H van Boom; W J van Blitterswijk; W H Moolenaar
Journal:  Biochem J       Date:  1995-04-15       Impact factor: 3.857

Review 6.  The autotaxin-lysophosphatidic acid-lysophosphatidic acid receptor cascade: proposal of a novel potential therapeutic target for treating glioblastoma multiforme.

Authors:  Sadaharu Tabuchi
Journal:  Lipids Health Dis       Date:  2015-06-18       Impact factor: 3.876

7.  Gintonin facilitates catecholamine secretion from the perfused adrenal medulla.

Authors:  Seung-Yeol Na; Ki-Hwan Kim; Mi-Sung Choi; Kang-Su Ha; Dong-Yoon Lim
Journal:  Korean J Physiol Pharmacol       Date:  2016-10-28       Impact factor: 2.016

8.  Receptor-mediated vascular smooth muscle migration induced by LPA involves p38 mitogen-activated protein kinase pathway activation.

Authors:  Zhi-Bin Zhou; Jian-Ping Niu; Zhi-Jun Zhang
Journal:  Int J Mol Sci       Date:  2009-07-13       Impact factor: 6.208

9.  Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

Authors:  K S Ha; J H Exton
Journal:  J Cell Biol       Date:  1993-12       Impact factor: 10.539

10.  Oral Administration of Gintonin Attenuates Cholinergic Impairments by Scopolamine, Amyloid-β Protein, and Mouse Model of Alzheimer's Disease.

Authors:  Hyeon-Joong Kim; Eun-Joo Shin; Byung-Hwan Lee; Sun-Hye Choi; Seok-Won Jung; Ik-Hyun Cho; Sung-Hee Hwang; Joon Yong Kim; Jung-Soo Han; ChiHye Chung; Choon-Gon Jang; Hyewon Rhim; Hyoung-Chun Kim; Seung-Yeol Nah
Journal:  Mol Cells       Date:  2015-08-07       Impact factor: 5.034
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