| Literature DB >> 8389937 |
S Carpenter1, S A Nadin-Davis, Y Wannemuehler, J A Roth.
Abstract
Transient expression assays using the reporter gene that encodes chloramphenicol acetyltransferase were used to identify cis-acting sequences necessary for bovine immunodeficiency-like virus (BIV) transactivation. Computer analyses identified two RNA stem-loop structures located immediately downstream of the transcription start site in the long terminal repeat. Deletion analysis of the long terminal repeat indicated that sequences containing the proximal stem-loop structure located between +4 and +31 are required for virus-specific transactivation. Therefore, BIV likely utilizes a mechanism of transactivation similar to that of the human and simian lentiviruses.Entities:
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Year: 1993 PMID: 8389937 PMCID: PMC237814
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103