Literature DB >> 8389719

Recombinant GABAA receptor function and ethanol.

E Sigel1, R Baur, P Malherbe.   

Abstract

Different combinations of cloned subunits of the rat brain GABAA receptor were expressed in Xenopus oocytes. Possible effects of ethanol on the expressed GABA-induced chloride current were determined. The consequence of replacing the gamma 2S subunit by the alternatively spliced variant gamma 2L was specifically tested on the responsiveness to ethanol. A significant stimulation of the GABA response was only observed at very high concentrations (> 60 mM) of ethanol. No differential response was observed between subunit combinations containing different gamma 2 subunit splice variants.

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Year:  1993        PMID： 8389719     DOI： 10.1016/0014-5793(93)81380-i

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

Review 1.  Consequences of the evolution of the GABA(A) receptor gene family.

Authors:  Mark G Darlison; Inderjit Pahal; Christian Thode
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

Review 2.  Low dose acute alcohol effects on GABA A receptor subtypes.

Authors:  Martin Wallner; H Jacob Hanchar; Richard W Olsen
Journal:  Pharmacol Ther       Date:  2006-07-11       Impact factor: 12.310

3.  Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.

Authors:  Dev Chandra; David F Werner; Jing Liang; Asha Suryanarayanan; Neil L Harrison; Igor Spigelman; Richard W Olsen; Gregg E Homanics
Journal:  Alcohol Clin Exp Res       Date:  2007-12-12       Impact factor: 3.455

Review 4.  Acute alcohol action and desensitization of ligand-gated ion channels.

Authors:  Alex M Dopico; David M Lovinger
Journal:  Pharmacol Rev       Date:  2009-03-06       Impact factor: 25.468

5.  Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.

Authors:  G E Homanics; N L Harrison; J J Quinlan; M D Krasowski; C E Rick; A L de Blas; A K Mehta; F Kist; R M Mihalek; J J Aul; L L Firestone
Journal:  Neuropharmacology       Date:  1999-02       Impact factor: 5.250

Review 6.  Ethanol, gamma-aminobutyrate type A receptors, and protein kinase C phosphorylation.

Authors:  R L Macdonald
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

7.  The interaction of trichloroethanol with murine recombinant 5-HT3 receptors.

Authors:  D L Downie; A G Hope; D Belelli; J J Lambert; J A Peters; K R Bentley; L J Steward; C Y Chen; N M Barnes
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

Review 8.  The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes.

Authors:  W Hevers; H Lüddens
Journal:  Mol Neurobiol       Date:  1998-08       Impact factor: 5.590

9.  Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors.

Authors:  F J Wan; F Berton; S G Madamba; W Francesconi; G R Siggins
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205

10.  Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation.

Authors:  B McElroy; A Zakaria; J D Glass; R A Prosser
Journal:  Neuroscience       Date:  2009-08-18       Impact factor: 3.590
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