Literature DB >> 838875

A sensitive urine-test method for monitoring the ingestion of isoniazid.

G A Ellard.   

Abstract

A method is described for monitoring the ingestion of isoniazid based on detecting its metabolites, isonicotinic acid, and isonicotinylglycine in the urine. The sensitivity of the method is high so that reliably positive results were obtained up to about 24 hours after the ingestion of 100 mg isoniazid. The method should facilitate monitoring the taking of isoniazid by tuberculosis patients and the use of isoniazid as a marker for assessing the regularity with which other drugs prescribed for self-administration are actually ingested.

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Year:  1977        PMID： 838875      PMCID： PMC476653          DOI： 10.1136/jcp.30.1.84

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  10 in total

1.  A NEW METHOD FOR THE DETERMINATION OF N-ACETYL ISONIAZID IN URINE OF AMBULATORY PATIENTS.

Authors:  L EIDUS; E J HAMILTON
Journal:  Am Rev Respir Dis       Date:  1964-04

2.  A simple spot test to determine whether a patient is taking isoniazid.

Authors:  J E KASIK; A HELLER; W LESTER; W R BARCLAY
Journal:  Am Rev Respir Dis       Date:  1962-02

3.  Pharmacokinetics of isoniazid metabolism in man.

Authors:  G A Ellard; P T Gammon
Journal:  J Pharmacokinet Biopharm       Date:  1976-04

4.  Sodium nitroprusside test for the detection of isoniazid and acetylisoniazid in urine.

Authors:  K V Nageswara Rao; L Eidus; C V Jacob; S Radhakrishna; S P Tripathy
Journal:  Tubercle       Date:  1967-03

5.  General considerations in the choice and management of regimens of chemotherapy for pulmonary tuberculosis.

Authors:  W Fox
Journal:  Bull Int Union Tuberc       Date:  1972-02

6.  The determination of isoniazid and its metabolites acetylisoniazid, monoacetylhydrazine, diacetylhydrazine, isonicotinic acid and isonicotinylglycine in serum and urine.

Authors:  G A Ellard; P T Gammon; S M Wallace
Journal:  Biochem J       Date:  1972-02       Impact factor: 3.857

7.  Organisational and administrative considerations in the diagnosis and treatment of pulmonary tuberculosis in the developing countries.

Authors:  W Fox
Journal:  Tubercle       Date:  1968-09

8.  The therapy of pulmonary tuberculosis in Kenya: a comparison of the results achieved in controlled clinical trials with those achieved by the routine treatment services.

Authors:  P W Kent; W Fox; A B Miller; A J Nunn; R Tall; D A Mitchison
Journal:  Tubercle       Date:  1970-03

9.  A comparison of various methods for the detection of isoniazid and its metabolites in urine.

Authors:  P Venkataraman; L Eidus; K Ramachandran; S P Tripathy
Journal:  Tubercle       Date:  1965-09

10.  The use of isoniazid as a marker to monitor the self-administration of medicaments.

Authors:  J E Stark; G A Ellard; P T Gammon; W Fox
Journal:  Br J Clin Pharmacol       Date:  1975-08       Impact factor: 4.335
  10 in total
  7 in total

1.  A comparison of a short half-life marker (low-dose isoniazid), a long half-life pharmacological indicator (low-dose phenobarbitone) and measurements of a controlled release 'therapeutic drug' (metoprolol, Metoros) in reflecting incomplete compliance by volunteers.

Authors:  E Hardy; S Kumar; S Peaker; M Feely; T Pullar
Journal:  Br J Clin Pharmacol       Date:  1990-09       Impact factor: 4.335

2.  Childhood tuberculosis at a Swiss university hospital: a 2-year study.

Authors:  C Barazzone; M Hofer; D Nussle; S Suter; T Rochat
Journal:  Eur J Pediatr       Date:  1993-10       Impact factor: 3.183

3.  Compliance of patients and physicians: experience and lessons from tuberculosis-II.

Authors:  W Fox
Journal:  Br Med J (Clin Res Ed)       Date:  1983-07-09

4.  A sensitive urine-test for monitoring the ingestion of isoniazid.

Authors:  L Eidus
Journal:  J Clin Pathol       Date:  1978-01       Impact factor: 3.411

5.  An evaluation of the potential use of isoniazid, acetylisoniazid and isonicotinic acid for monitoring the self-administration of drugs.

Authors:  G A Ellard; P J Jenner; P A Downs
Journal:  Br J Clin Pharmacol       Date:  1980-10       Impact factor: 4.335

6.  A simple, inexpensive urine test of smoking.

Authors:  H Peach; G A Ellard; P J Jenner; R W Morris
Journal:  Thorax       Date:  1985-05       Impact factor: 9.139

7.  Point-of-care urine tests for smoking status and isoniazid treatment monitoring in adult patients.

Authors:  Ioana Nicolau; Lulu Tian; Dick Menzies; Gaston Ostiguy; Madhukar Pai
Journal:  PLoS One       Date:  2012-09-28       Impact factor: 3.240
  7 in total

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