| Literature DB >> 8388472 |
R I Fryer1, P Zhang, R Rios, Z Q Gu, A S Basile, P Skolnick.
Abstract
The synthesis of a series of 2-phenylpyrazolo[4,3-c]quinolin-3-one derivatives and their in vitro biological evaluation as ligands for the benzodiazepine receptor are described. The in vitro activities, as determined by an analysis of GABA shift ratios, and binding affinities of these compounds to BZR are compared in terms of the electronic, lipophilic, and steric effect changes of their substituents.Entities:
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Year: 1993 PMID： 8388472 DOI： 10.1021/jm00063a017
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446