Literature DB >> 8388228

Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma.

S F Ding1, J D Delhanty, L Bowles, J S Dooley, C B Wood, N A Habib.   

Abstract

It has been established that loss of tumour suppressor genes is crucial in carcinogenesis. There has been no reported study on searching for tumour suppressor genes in cholangiocarcinomas as yet. In order to investigate the loss of heterozygosity (LOH), which may represent such gene loss, in cholangiocarcinoma, we studied 14 patients with this tumour using restriction fragment length polymorphism analysis. Twenty-two probes assigned to chromosomes 1, 5, 7, 9, 11, 12, 13, 14, 16, 17 and 18 were used. Allelic losses were found in chromosomal regions 5q35-qter and 17p13. Loss of genetic material in these regions in cholangiocarcinoma was shared with hepatocellular carcinoma. Probes for other chromosomes have as yet shown no consistent LOH. In conclusion, this study for the first time showed LOH on chromosomes 5 and 17 in cholangiocarcinoma.

Entities:  

Mesh：

Year:  1993        PMID： 8388228      PMCID： PMC1968440          DOI： 10.1038/bjc.1993.184

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  33 in total

1.  Chromosomal breakpoints in cholangiocarcinoma cell lines.

Authors:  P D Storto; S L Saidman; A J Demetris; E Letessier; T L Whiteside; S M Gollin
Journal:  Genes Chromosomes Cancer       Date:  1990-11       Impact factor: 5.006

2.  Systematic cloning of human minisatellites from ordered array charomid libraries.

Authors:  J A Armour; S Povey; S Jeremiah; A J Jeffreys
Journal:  Genomics       Date:  1990-11       Impact factor: 5.736

3.  A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations.

Authors:  R M Cawthon; R Weiss; G F Xu; D Viskochil; M Culver; J Stevens; M Robertson; D Dunn; R Gesteland; P O'Connell
Journal:  Cell       Date:  1990-07-13       Impact factor: 41.582

4.  Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

Authors:  D Viskochil; A M Buchberg; G Xu; R M Cawthon; J Stevens; R K Wolff; M Culver; J C Carey; N G Copeland; N A Jenkins
Journal:  Cell       Date:  1990-07-13       Impact factor: 41.582

5.  Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.

Authors:  K W Kinzler; M C Nilbert; B Vogelstein; T M Bryan; D B Levy; K J Smith; A C Preisinger; S R Hamilton; P Hedge; A Markham
Journal:  Science       Date:  1991-03-15       Impact factor: 47.728

6.  MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.

Authors:  P G Ashton-Rickardt; A H Wyllie; C C Bird; M G Dunlop; C M Steel; R G Morris; J Piris; P Romanowski; R Wood; R White
Journal:  Oncogene       Date:  1991-10       Impact factor: 9.867

7.  Identification and characterization of the familial adenomatous polyposis coli gene.

Authors:  J Groden; A Thliveris; W Samowitz; M Carlson; L Gelbert; H Albertsen; G Joslyn; J Stevens; L Spirio; M Robertson
Journal:  Cell       Date:  1991-08-09       Impact factor: 41.582

8.  Identification of FAP locus genes from chromosome 5q21.

Authors:  K W Kinzler; M C Nilbert; L K Su; B Vogelstein; T M Bryan; D B Levy; K J Smith; A C Preisinger; P Hedge; D McKechnie
Journal:  Science       Date:  1991-08-09       Impact factor: 47.728

Review 9.  Tumor suppressor genes.

Authors:  R A Weinberg
Journal:  Science       Date:  1991-11-22       Impact factor: 47.728

10.  Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.

Authors:  M Miyaki; M Seki; M Okamoto; A Yamanaka; Y Maeda; K Tanaka; R Kikuchi; T Iwama; T Ikeuchi; A Tonomura
Journal:  Cancer Res       Date:  1990-11-15       Impact factor: 12.701
View more
  6 in total

1.  Prognostic significance of microsatellite alterations at 1p36 in cholangiocarcinoma.

Authors:  Temduang Limpaiboon; Sumonta Tapdara; Patcharee Jearanaikoon; Banchob Sripa; Vajarabhongsa Bhudhisawasdi
Journal:  World J Gastroenterol       Date:  2006-07-21       Impact factor: 5.742

2.  Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma.

Authors:  A Tannapfel; F Sommerer; M Benicke; A Katalinic; D Uhlmann; H Witzigmann; J Hauss; C Wittekind
Journal:  Gut       Date:  2003-05       Impact factor: 23.059

3.  Use of microsatellite marker loss of heterozygosity in accurate diagnosis of pancreaticobiliary malignancy from brush cytology samples.

Authors:  A Khalid; R Pal; E Sasatomi; P Swalsky; A Slivka; D Whitcomb; S Finkelstein
Journal:  Gut       Date:  2004-12       Impact factor: 23.059

4.  The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34.

Authors:  E A Emslie; T A Jones; D Sheer; S M Keyse
Journal:  Hum Genet       Date:  1994-05       Impact factor: 4.132

5.  Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine?

Authors:  Mia Kumar; Xuelian Zhao; Xin Wei Wang
Journal:  Cell Biosci       Date:  2011-01-24       Impact factor: 7.133

6.  Molecular diagnosis of primary liver cancer by microsatellite DNA analysis in the serum.

Authors:  Y-C Chang; C-L Ho; Helen H-W Chen; T-T Chang; W-W Lai; Y-C Dai; W-Y Lee; N-H Chow
Journal:  Br J Cancer       Date:  2002-12-02       Impact factor: 7.640
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.