| Literature DB >> 8388038 |
E A Young1, N H Neff, M Hadjiconstantinou.
Abstract
Aromatic L-amino acid decarboxylase (AAAD) activity of mouse striatum and midbrain increased after an intracerebroventricular injection of either forskolin or 8-bromo-cyclic AMP. The increase was transient, peaking between 15 and 30 min and returning to baseline by approximately 90 min. The increase of AAAD activity after forskolin was not affected by pretreatment with cycloheximide. Kinetic studies indicated an apparent increase of Vmax with little change of the Km for L-DOPA or pyridoxal 5'-phosphate. We conclude that AAAD activity of striatum and midbrain can be modulated by a cyclic AMP-dependent process.Entities:
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Year: 1993 PMID： 8388038 DOI： 10.1111/j.1471-4159.1993.tb03525.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372